2. Gene
  3. MAPKAP1 - MAPK associated protein 1 Gene

MAPKAP1 - MAPK associated protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAPK 相关蛋白 1

种属: Homo sapiens

同用名: MIP1; SIN1; JC310; SIN1b; SIN1g

基因 ID: 79109 | 基因类型: protein coding

关于 MAPKAP1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,437,394-125,707,208 (from NCBI)

This gene has 20 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 18.8), testis (RPKM 17.4) and 25 other tissues.

功能概要

该基因编码的蛋白质与酵母 SIN1 蛋白高度相似，后者是一种应激激活蛋白激酶。已经描述了编码不同同种型的选择性剪接转录物变体。已经确定了该基因转录本的替代聚腺苷酸化位点以及替代 3' UTR。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

MAPKAP1 基因产物(6)

mRNA Protein Name
NM_001006617.3 NP_001006618.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 1
NM_001006618.2 NP_001006619.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 5
NM_001006619.2 NP_001006620.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 3
NM_001006620.2 NP_001006621.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 4
NM_001006621.2 NP_001006622.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 4
NM_024117.4 NP_077022.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
29567957 GOA
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
17303383 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
17303383 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: 通过直接分析推断
17303383 GOA
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: 通过直接分析推断
17303383 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
17303383 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24365180 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
21177249 GOA
enables small GTPase binding IDA
IDA: 通过直接分析推断
17303383 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of Ras protein signal transduction IMP
IMP: 通过突变表型推断
17303383 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17303383 GOA
part of TORC2 complex IPI
IPI: 通过物理相互作用推断
17461779 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17303383 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPKAP1 蛋白结构

SIN1

SIN1: Stress-activated map kinase interacting protein 1 (SIN1) (18 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
蛋白主名 其他名称

target of rapamycin complex 2 subunit MAPKAP1

MEKK2-interacting protein 1

关联疾病

疾病名称 别名
Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay

Aarskog-Ose-Pande Syndrome

Lipodystrophy, Partial, With Rieger Anomaly And Short Stature

Lipodystrophy-Rieger Anomaly-Diabetes Syndrome

Rieger Anomaly-Partial Lipodystrophy Syndrome

Partial Lipodystrophy With Rieger Anomaly And Short Stature

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay

Growth Retardation-Rieger Anomaly

Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay

SHORTS
Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy

Severe Myoclonic Epilepsy In Infancy

Smei

Epileptic Encephalopathy, Early Infantile, 6

DRVT

Developmental And Epileptic Encephalopathy 6a

Dee6a

Eiee6

Developmental And Epileptic Encephalopathy, 6

Dee6

Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy

Sme

Severe Myoclonus Epilepsy Of Infancy

Borderline Smei

Smeb

Smeb-M

Smeb-O

Smeb-Sw

Smei-Borderland

Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

ICEGTC

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N1190 DL-Syringaresinol Inhibitor / 否
HY-N1326 Santamarine / 否
HY-RS08130 MAPKAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MAPKAP1 MGD MGI:2444554
Felis catus MAPKAP1 VGNC VGNC:63382
Bos taurus MAPKAP1 VGNC VGNC:31228
Rattus norvegicus MAPKAP1 RGD RGD:1305363
Macaca mulatta MAPKAP1 VGNC VGNC:74531
Canis familiaris MAPKAP1 VGNC VGNC:43005
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