DHRS11 - dehydrogenase/reductase 11 Gene

中文名称：脱氢酶/还原酶 11

种属: Homo sapiens

同用名: ARPG836; SDR24C1; spDHRS11

基因 ID: 79154 | 基因类型: protein coding

关于 DHRS11

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,591,879-36,600,804 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 361 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 115.7), small intestine (RPKM 99.1) and 4 other tissues.

功能概要

启用 17-β-羟基类固醇脱氢酶 (NADP+) 活性； 17-β-酮类固醇还原酶活性；和 3-酮甾醇还原酶活性。参与类固醇的生物合成过程。预测位于细胞外区域。 [由基因组资源联盟提供，2022 年 4 月]

Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

DHRS11 基因产物(1)

mRNA	Protein	Name
NM_024308.4	NP_077284.2	dehydrogenase/reductase SDR family member 11 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity	IDA IDA: 通过直接分析推断	26920053	GOA
enables 17-beta-ketosteroid reductase (NADPH) activity	IDA IDA: 通过直接分析推断	26920053	GOA
enables 3-keto sterol reductase activity	IDA IDA: 通过直接分析推断	26920053	GOA
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA IDA: 通过直接分析推断	26920053	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in steroid biosynthetic process	IDA IDA: 通过直接分析推断	26920053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHRS11 蛋白结构

adh_short

0
100
200
260 a.a.

蛋白主名

其他名称

dehydrogenase/reductase SDR family member 11

17-beta-hydroxysteroid dehydrogenase

关联疾病

疾病名称

别名

17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency

17-Ksr Deficiency	Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency
Pseudohermaphroditism, Male, With Gynecomastia	17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency
Testosterone 17-Beta-Dehydrogenase Deficiency	17-Ketosteroid Reductase Deficiency Of Testis
17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency	17-Ketoreductase Deficiency
17-Ketosteroidreductase Deficiency	46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency
Male Pseudohermaphroditism With Gynecomastia	17 Alpha Ksr Deficiency
17 Alpha Ketosteroid Reductase Deficiency Of Testis	17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency
Male Pseudoherma-Phroditism With Gynecomastia	Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency
Male Pseudohermaphrodism With Gynecomastia	MPH
17-Hydroxysteroid Dehydrogenase Deficiency

Mixed Gonadal Dysgenesis

Gonadal Dysgenesis Mixed

Gonadal Dysgenesis, Mixed

D-Bifunctional Protein Deficiency

Bifunctional Peroxisomal Enzyme Deficiency	17-Beta-Hydroxysteroid Dehydrogenase Iv Deficiency
Dbp Deficiency	Peroxisomal Bifunctional Enzyme Deficiency
Pbfe Deficiency	Bifunctional Enzyme Deficiency
Pseudo-Zellweger Syndrome	Zellweger-Like Syndrome
DBPD	Protein Deficiency, D-Bifunctional

Androgen Insensitivity, Partial

Partial Androgen Insensitivity Syndrome	Reifenstein Syndrome
PAIS	Androgen Insensitivity, Partial, With Or Without Breast Cancer
Familial Incomplete Male Pseudohermaphroditism, Type 1	Androgen Insensitivity Syndrome, Partial
Androgen Resistance Syndrome, Partial	Reifenstein Syndrome, Partial
Partial Androgen Resistance Syndrome	Androgen Insensitivity Partial With Or Without Breast Cancer
Androgen Insensitivity Syndrome Partial	Insensitivity Syndrome, Androgen, Partial, With/Without Breast Cancer Syndrome

Complete Androgen Insensitivity Syndrome

Cais	Complete Androgen Resistance Syndrome
Androgen Insensitivity Syndrome Complete	Androgen Insensitivity, Complete
Androgen-Insensitivity Syndrome	Testicular Feminization

Estrogen Excess

Hyperestrogenism

Leydig Cell Hypoplasia

46,Xy Disorder Of Sex Development Due To Lh Resistance Or Lhb Deficiency	46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
46,Xy Dsd Due To Lh Resistance Or Lhb Deficiency	46,Xy Dsd Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
46,Xy Disorder Of Sex Development Due To Lh Defects	Lh Resistance Due To Lh Receptor Deactivation
Leydig Cell Agenesis	Male Hypergonadotropic Hypogonadism Due To Lhcgr Defect
Male Pseudohermaphroditism Due To Lh Resistance Or Lhb Deficiency	Male Pseudohermaphroditism Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
Lch	Hypoplasia, Leydig Cell

Pseudohermaphroditism

Indeterminate Sex And Pseudohermaphroditism

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Syndromic X-Linked Intellectual Disability Type 10

Hsd10 Deficiency, Atypical Type	Hsd10 Disease, Atypical Type
X-Linked Intellectual Disability-Choreoathetosis-Abnormal Behavior Syndrome	Mrxs10
Mental Retardation, X-Linked, Syndromic 10

Aromatase Excess Syndrome

AEXS	Increased Aromatase Activity
Familial Hyperestrogenism	Hereditary Prepubertal Gynecomastia
Aromatase Activity, Increased	Familial Gynecomastia Due To Increased Aromatase Activity
Hereditary Gynecomastia	Gynecomastia, Familial
Familial Gynecomastia

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome	Ers
Amelogenesis Imperfecta Type 1g	AI1G
Enamel-Renal-Gingival Syndrome	Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome
Aigfs	Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis
Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis	Amelogenesis Imperfecta Type Ig
Amelogenesis Imperfecta-Nephrocalcinosis Syndrome	Amelogenesis Imperfecta 1g
Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis	Amelogenesis Imperfecta Nephrocalcinosis

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式 Pre-designed Sets	纯度	是否罕见病否
HY-RS03739	DHRS11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	DHRS11	VGNC	VGNC:61469
Canis familiaris	DHRS11	VGNC	VGNC:39932
Bos taurus	DHRS11	VGNC	VGNC:28040
Mus musculus	DHRS11	MGD	MGI:2652816
Macaca mulatta	DHRS11	VGNC	VGNC:71792
Rattus norvegicus	DHRS11	RGD	RGD:1307935

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DHRS11 - dehydrogenase/reductase 11 Gene

关于 DHRS11

功能概要

DHRS11 基因产物(1)

DHRS11 蛋白结构

关联疾病

直系同源

热门区域

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DHRS11 - dehydrogenase/reductase 11 Gene

关于 DHRS11

功能概要

DHRS11 基因产物(1)

DHRS11 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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