HSD17B8 - hydroxysteroid 17-beta dehydrogenase 8 Gene

中文名称：羟基类固醇 17-β 脱氢酶 8

种属: Homo sapiens

同用名: KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9

关于 HSD17B8

功能概要

在小鼠中，Ke6 蛋白是一种 17-β-羟基类固醇脱氢酶，可以调节具有生物活性的雌激素和雄激素的浓度。它优先是一种氧化酶并使雌二醇、睾酮和二氢睾酮失活。然而，该酶具有一定的还原活性，可以从雌酮合成雌二醇。该基因编码的蛋白质与 Ke6 相似，是短链脱氢酶超家族的成员。已检测到该基因的可变剪接转录本，但尚未确定该变体的全长性质。[RefSeq 提供，2008 年 7 月]

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative Enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the Enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]