BHLHE41 - basic helix-loop-helix family member e41 Gene

中文名称：基本螺旋-环-螺旋家族成员 e41

种属: Homo sapiens

同用名: DEC2; FNSS1; hDEC2; BHLHB3; SHARP1

基因 ID: 79365 | 基因类型: protein coding

关于 BHLHE41

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:26,120,030-26,125,037 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 31.2), brain (RPKM 21.3) and 19 other tissues.

功能概要

该基因编码在各种组织中表达的基本螺旋-环-螺旋蛋白。编码的蛋白质可以与 ARNTL 相互作用或竞争 PER1 启动子中的 E-box 结合位点，并抑制 CLOCK/ARNTL 对 PER1 的反式激活。该基因被认为与昼夜节律和细胞分化的控制有关。该基因的缺陷与短睡眠表型有关。[RefSeq 提供，2014 年 2 月]

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]

BHLHE41 基因产物(1)

mRNA	Protein	Name
NM_030762.3	NP_110389.1	class E basic helix-loop-helix protein 41

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	19786558	GOA
enables E-box binding	IDA IDA: 通过直接分析推断	14672706	GOA
enables bHLH transcription factor binding	IPI IPI: 通过物理相互作用推断	15193144	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19786558	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	15193144	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	14672706	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BHLHE41 蛋白结构

HLH

Hairy_orange

0
100
200
300
400
482 a.a.

蛋白主名

其他名称

class E basic helix-loop-helix protein 41

basic helix-loop-helix domain containing, class B, 3

BHLHE41 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BHLHE41	Q9C0J9	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	22801492

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Short Sleep, Familial Natural, 1

FNSS1	Short Sleep Phenotype
Sleep, Short, Natural, Familial, Type 1

Advanced Sleep Phase Syndrome, Familial, 1

Advanced Sleep Phase Syndrome 1	FASPS1
Familial Advanced Sleep Phase Syndrome 1	Sleep Phase Syndrome, Advanced, Familial, Type 1

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Erythrocytosis, Familial, 5

ECYT5

Familial Erythrocytosis 5

Erythrocytosis, Familial, 3

ECYT3	Familial Erythrocytosis 3
Erythrocytosis, Familial, Type 3

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01494	BHLHE41 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	BHLHE41	RGD	RGD:70900
Mus musculus	BHLHE41	MGD	MGI:1930704
Bos taurus	BHLHE41	VGNC	VGNC:26487
Canis familiaris	BHLHE41	VGNC	VGNC:57419
Macaca mulatta	BHLHE41	VGNC	VGNC:108327

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BHLHE41 - basic helix-loop-helix family member e41 Gene

关于 BHLHE41

功能概要

BHLHE41 基因产物(1)

BHLHE41 蛋白结构

BHLHE41 蛋白互作信息

关联疾病

直系同源

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BHLHE41 - basic helix-loop-helix family member e41 Gene

关于 BHLHE41

功能概要

BHLHE41 基因产物(1)

BHLHE41 蛋白结构

BHLHE41 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z