SMC6 - structural maintenance of chromosomes 6 Gene

中文名称：6 号染色体的结构维护

种属: Homo sapiens

同用名: SMC-6; hSMC6; SMC6L1

基因 ID: 79677 | 基因类型: protein coding

关于 SMC6

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,663,812-17,753,810 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 1 paralogue. Broad expression in testis (RPKM 13.9), lymph node (RPKM 7.0) and 24 other tissues.

功能概要

启用泛素蛋白连接酶结合活性。参与多个过程，包括细胞衰老；染色体分离的正调控；以及通过重组维持端粒。位于染色体和核体中。 Smc5-Smc6 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC6 基因产物(2)

mRNA	Protein	Name
NM_001142286.2	NP_001135758.1	structural maintenance of chromosomes protein 6
NM_024624.6	NP_078900.1	structural maintenance of chromosomes protein 6

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA secondary structure binding	IDA IDA: 通过直接分析推断	28095508	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11408570	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	25931565	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	11408570	GOA
involved in cellular senescence	IMP IMP: 通过突变表型推断	17589526	GOA
involved in negative regulation by host of viral genome replication	IDA IDA: 通过直接分析推断	28095508	GOA
involved in positive regulation of chromosome segregation	IMP IMP: 通过突变表型推断	25931565	GOA
involved in telomere maintenance via recombination	IMP IMP: 通过突变表型推断	17589526	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in PML body	IDA IDA: 通过直接分析推断	17589526	GOA
part of Smc5-Smc6 complex	IDA IDA: 通过直接分析推断	18086888	GOA
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	17589526	GOA
located in interchromatin granule	IDA IDA: 通过直接分析推断	11408570	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	28095508	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11408570	GOA
located in site of double-strand break	IDA IDA: 通过直接分析推断	25931565	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMC6 蛋白结构

SMC_N

0
200
400
600
800
1000
1091 a.a.

蛋白主名

其他名称

structural maintenance of chromosomes protein 6

SMC protein 6

SMC6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SMC6	Q96SB8	NSMCE3	Homo sapiens	Q96MG7	Anti Bait CoIP	18086888
种属内	SMC6	Q96SB8	NSMCE3	Homo sapiens	Q96MG7	Anti Tag CoIP	27427983
种属内	SMC6	Q96SB8	NSMCE3	Homo sapiens	Q96MG7	Anti Tag CoIP	26496610
种属内	SMC6	Q96SB8	NSMCE1	Homo sapiens	Q8WV22	Anti Bait CoIP	18086888
种属内	SMC6	Q96SB8	NSMCE1	Homo sapiens	Q8WV22	Anti Tag CoIP	26496610
种属内	SMC6	Q96SB8	NSMCE2	Homo sapiens	Q96MF7	Anti Tag CoIP	33961781
种属内	SMC6	Q96SB8	NSMCE2	Homo sapiens	Q96MF7	Anti Bait CoIP	18086888
种属内	SMC6	Q96SB8	NSMCE2	Homo sapiens	Q96MF7	Anti Tag CoIP	26496610
种属内	SMC6	Q96SB8	SLF2	Homo sapiens	Q8IX21	Pull Down	32389690
种属内	SMC6	Q96SB8	SLF2	Homo sapiens	Q8IX21	Anti Tag CoIP	32389690
种属内	SMC6	Q96SB8	SLF2	Homo sapiens	Q8IX21	Anti Tag CoIP	26496610
种属内	SMC6	Q96SB8	SMC5	Homo sapiens	Q8IY18	Anti Tag CoIP	33961781
种属内	SMC6	Q96SB8	SMC5	Homo sapiens	Q8IY18	Anti Tag CoIP	26496610
种属内	SMC6	Q96SB8	SMC5	Homo sapiens	Q8IY18	Anti Bait CoIP	18086888

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13422	SMC6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SMC6	MGD	MGI:1914491
Rattus norvegicus	SMC6	RGD	RGD:1311214
Bos taurus	SMC6	VGNC	VGNC:35003
Canis familiaris	SMC6	VGNC	VGNC:46547
Felis catus	SMC6	VGNC	VGNC:65480
Macaca mulatta	SMC6	VGNC	VGNC:77746

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SMC6 - structural maintenance of chromosomes 6 Gene

关于 SMC6

功能概要

SMC6 基因产物(2)

SMC6 蛋白结构

SMC6 蛋白互作信息

关联疾病

直系同源

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SMC6 - structural maintenance of chromosomes 6 Gene

关于 SMC6

功能概要

SMC6 基因产物(2)

SMC6 蛋白结构

SMC6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z