2. Gene
  3. CALCB - calcitonin related polypeptide beta Gene

CALCB - calcitonin related polypeptide beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：降钙素相关多肽β

种属: Homo sapiens

同用名: CALC2; CGRP2; CGRP-II

基因 ID: 797 | 基因类型: protein coding

关于 CALCB

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,073,593-15,078,637 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 2 paralogues. Restricted expression toward thyroid (RPKM 12.3).

功能概要

预测可启用降钙素受体结合活性。预计参与腺苷酸环化酶激活 G 蛋白偶联受体信号通路和细胞溶质钙离子浓度的调节。预测位于细胞外区域。预计在细胞外空间活跃。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

CALCB 基因产物(1)

mRNA Protein Name
NM_000728.4 NP_000719.1 calcitonin gene-related peptide 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CALCB 蛋白结构

Calc_CGRP_IAPP

Calc_CGRP_IAPP: Calcitonin / CGRP / IAPP family (1 - 125)

  • 0
  • 100
  • 127 a.a.
蛋白主名 其他名称

calcitonin gene-related peptide 2

beta-CGRP

CALCB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CALCB P10092 CIB1 Homo sapiens Q99828
Y2H Prey Pooling
32296183
种属内
CALCB P10092 CIB1 Homo sapiens Q99828
Validated Y2H
32296183
种属内
CALCB P10092 CIB1 Homo sapiens Q99828
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CALCB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7706 CALCB Protein, Human (HEK293, hFc) P10092 (A26-F118) ≥95%
HY-P75600 CALCB Protein, Human (HEK293, mFc) P10092 (A26-F118) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 17

IMD17

Cd3-Gamma Deficiency

Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive

Combined Immunodeficiency Due To Cd3gamma Deficiency

Immunodeficiency 17, Cd3 Gamma Deficient

Cd3gamma Deficiency

Immunodeficiency, Type 17
Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma

Familial Medullary Thyroid Carcinoma

MTC

Medullary Thyroid Cancer

Fmtc

Mtc1

Thyroid Cancer, Medullary

Thyroid Carcinoma, Medullary

Familial Mtc

Thyroid Carcinoma Medullary

Carcinoma, Thyroid, Medullary, Familial

Medullary Carcinoma Of Thyroid

Medullary Carcinoma With Amyloid Stroma, Unspecified Site

Medullary Carcinoma With Amyloid Stroma Of Thyroid
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01829 CALCB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CALCB RGD RGD:620997
Macaca mulatta CALCB VGNC VGNC:70515
Mus musculus CALCB MGD MGI:2151254
Others CALCB NCBI
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