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  2. BORA - BORA aurora kinase A activator Gene

BORA - BORA aurora kinase A activator Gene

中文名称:BORA 极光激酶 A 激活因子

种属: Homo sapiens

同用名: C13orf34

基因 ID: 79866 | 基因类型: protein coding

关于 BORA

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,727,923-72,756,196 (from NCBI)

This gene has 9 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in lymph node (RPKM 4.2), appendix (RPKM 3.1) and 24 other tissues.

功能概要

BORA 是蛋白激酶 Aurora A (AURKA;MIM 603072) 的激活剂,它是有丝分裂期间中心体成熟、纺锤体装配和不对称蛋白定位所必需的 (Hutterer 等人,2006 [PubMed 16890155]) 。[OMIM 提供, 2008 年 3 月]

BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

BORA 基因产物(4)

mRNA Protein Name
NM_001286746.3 NP_001273675.2 protein aurora borealis isoform 1
NM_001286747.2 NP_001273676.1 protein aurora borealis isoform 3
NM_001366664.2 NP_001353593.1 protein aurora borealis isoform 4
NM_024808.5 NP_079084.4 protein aurora borealis isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16890155 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
18521620 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of mitotic nuclear division IMP
IMP: 通过突变表型推断
18521620 GOA
involved in regulation of mitotic spindle organization IMP
IMP: 通过突变表型推断
18521620 GOA
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
18521620 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BORA 蛋白结构

BORA_N

BORA_N: Protein aurora borealis N-terminus (1 - 205)

  • 0
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  • 200
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  • 500
  • 559 a.a.
蛋白主名 其他名称

protein aurora borealis

BORA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BORA Q6PGQ7 AURKA Homo sapiens O14965 16890155
种属间: 跨种属相互作用 种属内: 同种属相互作用

BORA 抗体

目录号 产品名 应用 反应物种
HY-P82547 Bora Antibody (YA2292) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma

T2-Low Asthma

Type 2 Low Endotype

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BORA VGNC VGNC:70376
Canis familiaris BORA VGNC VGNC:38499
Rattus norvegicus BORA RGD RGD:1309522
Bos taurus BORA VGNC VGNC:26541
Felis catus BORA VGNC VGNC:60150
Mus musculus BORA MGD MGI:1924994