WLS - Wnt ligand secretion mediator Gene

中文名称：Wnt 配体分泌介质

种属: Homo sapiens

同用名: EVI; MRP; ZKS; GPR177; mig-14; C1orf139

基因 ID: 79971 | 基因类型: protein coding

关于 WLS

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,098,459-68,232,546 (from NCBI)

This gene has 14 transcripts (splice variants), 241 orthologues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 32.7), gall bladder (RPKM 31.7) and 24 other tissues.

功能概要

启用 Wnt 蛋白结合活性和相同的蛋白结合活性。参与细胞通讯和蛋白质转运的正向调节。位于多种细胞成分中，包括高尔基体；早期内体；和内质网膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

WLS 基因产物(3)

mRNA	Protein	Name
NM_001002292.4	NP_001002292.3	protein wntless homolog isoform 2
NM_001193334.1	NP_001180263.1	protein wntless homolog isoform 3
NM_024911.7	NP_079187.3	protein wntless homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Wnt-protein binding	IPI IPI: 通过物理相互作用推断	24768165	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	28734904	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18160348	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Wnt protein secretion	IMP IMP: 通过突变表型推断	24768165	GOA
involved in intracellular protein transport	IMP IMP: 通过突变表型推断	16678095	GOA
involved in positive regulation of Wnt protein secretion	IMP IMP: 通过突变表型推断	16678095	GOA
involved in positive regulation of Wnt signaling pathway	IMP IMP: 通过突变表型推断	16678095	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	17804805	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	16678095	GOA
located in Golgi membrane	IDA IDA: 通过直接分析推断	24768165	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	16678095	GOA
located in early endosome	IDA IDA: 通过直接分析推断	18160348	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	24768165	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18160348	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	18160348	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WLS 蛋白结构

MIG-14_Wnt-bd

0
100
200
300
400
500
541 a.a.

蛋白主名

其他名称

protein wntless homolog

G protein-coupled receptor 177

WLS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Y2H	23840749
种属内	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Anti Tag CoIP	20214800
种属内	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Ub Reconstruction	23840749
种属内	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Ub Reconstruction	28298427
种属内	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Anti Bait CoIP	20214800
种属内	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Ub Reconstruction	20214800
种属内	WLS	Q5T9L3	SLC6A3	Homo sapiens	Q01959	Anti Tag CoIP	28734904
种属内	WLS	Q5T9L3	SLC6A3	Homo sapiens	Q01959	Pull Down	28734904

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Zaki Syndrome

ZKS	Microcephaly, Progressive, With Developmental Delay, Cupped Ears, And Dysmorphic Features

Volkmann Contracture

Ischemic Contracture

Volkmann'S Ischemic Contracture

Tracheal Disease

Tracheal Diseases	Tracheal Anomaly
Tracheal Disorders

Focal Dermal Hypoplasia

Goltz Syndrome	Goltz-Gorlin Syndrome
FDH	FODH
Dhof	Goltz Gorlin Syndrome
Hypoplasia, Dermal, Focal

Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome	Nfia-Related Disorder
Chromosome 1, Monosomy 1p32	BRMUTD
1p31p32 Microdeletion Syndrome	Nfia Haploinsufficiency
Del(1)(P31p32)	Monosomy 1p31p32
Nfia-Related Disorders

Thyroid Dyshormonogenesis 4

Deiodinase Deficiency	TDH4
Iodotyrosine Dehalogenase Deficiency	Thyroid Hormonogenesis, Genetic Defect In, 4
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4	Genetic Defect In Thyroid Hormonogenesis 4
Chdh4	Congenital Hypothyroidism Due To Dyshormonogenesis Type 4
Genetic Defect In Thyroid Hormonogenesis Type 4

Tracheomalacia

Congenital Tracheomalacia	Congenital Major Airway Collapse
Tracheomalacia, Congenital	Type 1 Tracheomalacia

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis	Worth Syndrome
Osteosclerosis, Autosomal Dominant	Hyperostosis, Endosteal
Endosteal Hyperostosis, Worth Type	Worth Disease
Autosomal Dominant Endosteal Hyperostosis	Autosomal Dominant Osteosclerosis, Worth Type
Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus	Autosomal Dominant Osteosclerosis
Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus	Worth'S Syndrome
Worth Type Autosomal Dominant Osteosclerosis	Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus
Osteosclerosis, Autosomal Dominant, Worth Type	WENHY
Endosteal Hyperostosis Autosomal Dominant	Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus
Osteosclerosis Autosomal Dominant	Acquired Osteosclerosis

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15822	WLS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	WLS	RGD	RGD:735139
Canis familiaris	WLS	VGNC	VGNC:48417
Mus musculus	WLS	MGD	MGI:1915401
Macaca mulatta	WLS	VGNC	VGNC:79839
Bos taurus	WLS	VGNC	VGNC:36948
Felis catus	WLS	VGNC	VGNC:67076

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WLS - Wnt ligand secretion mediator Gene

关于 WLS

功能概要

WLS 基因产物(3)

WLS 蛋白结构

WLS 蛋白互作信息

关联疾病

直系同源

热门区域

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WLS - Wnt ligand secretion mediator Gene

关于 WLS

功能概要

WLS 基因产物(3)

WLS 蛋白结构

WLS 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z