PSCA - prostate stem cell antigen Gene

中文名称：前列腺干细胞抗原

种属: Homo sapiens

同用名: PRO232; lncPSCA

基因 ID: 8000 | 基因类型: protein coding

关于 PSCA

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,670,297-142,682,725 (from NCBI)

This gene has 4 transcripts (splice variants), 93 orthologues and 2 paralogues. Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue.

功能概要

该基因编码糖基磷脂酰肌醇锚定细胞膜糖蛋白。除了在前列腺中高度表达外，它还在膀胱、胎盘、结肠、肾脏和胃中表达。该基因在大部分前列腺癌中上调，并且也在膀胱癌和胰腺癌中检测到。该基因包含一个多态性，在某些个体中会产生上游起始密码子；这种多态性被认为与某些胃癌和膀胱癌的风险有关。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 2 月]

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

PSCA 基因产物(1)

mRNA	Protein	Name
NM_005672.5	NP_005663.2	prostate stem cell antigen preproprotein

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables acetylcholine receptor binding	IDA IDA: 通过直接分析推断	25680266	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	25680266	GOA
involved in regulation of neurotransmitter receptor activity	IDA IDA: 通过直接分析推断	25680266	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSCA 蛋白结构

UPAR_LY6

0
100
114 a.a.

蛋白主名

其他名称

prostate stem cell antigen

重组 PSCA 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78013	PSCA Protein, Human (HEK293, Fc)	O43653 (L12-S86)	≥95%

关联疾病

疾病名称

别名

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Duodenal Ulcer

Stress Ulcer	Curling Ulcer
Stress Ulcer Of Stomach	Curling'S Ulcers
Duodenal Ulcer Disease	Duodenal Ulcers
Duodenal Peptic Ulcer

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Cardia Cancer

Ca Cardia - Stomach

Malignant Neoplasm Of Cardia Of Stomach

Colloid Carcinoma Of The Pancreas

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11271	PSCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PSCA	MGD	MGI:1919623
Rattus norvegicus	PSCA	RGD	RGD:1594221
Macaca mulatta	PSCA	VGNC	VGNC:99472
Canis familiaris	PSCA	VGNC	VGNC:56075
Others	PSCA	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PSCA - prostate stem cell antigen Gene

关于 PSCA

功能概要

PSCA 基因产物(1)

PSCA 蛋白结构

重组 PSCA 蛋白

关联疾病

直系同源

热门区域

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PSCA - prostate stem cell antigen Gene

关于 PSCA

功能概要

PSCA 基因产物(1)

PSCA 蛋白结构

重组 PSCA 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z