PSCA 蛋白, Human (HEK293, Fc)

PSCA protein plays a role in the regulation of cell proliferation and has shown an inhibitory effect on cell proliferation in vitro. In addition, PSCA may act as a modulator of nicotinic acetylcholine receptor (nAChR) activity, specifically inhibiting nicotine-induced signaling in vitro, possibly affecting α-3:β-2 or α-7-containing nAChRs. PSCA Protein, Human (HEK293, Fc) is the recombinant human-derived PSCA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PSCA Protein, Human (HEK293, Fc) is 75 a.a., with molecular weight of 40-50 kDa.

PSCA 蛋白似乎在细胞增殖调节中发挥作用，在体外表现出细胞增殖抑制活性。此外，PSCA 可以作为烟碱乙酰胆碱受体 (nAChR) 活性的调节剂，特别是在体外，它抑制尼古丁诱导的信号传导，可能涉及含有 α-3:β-2 或 α-7 的 nAChR。这种双重功能表明 PSCA 参与与增殖控制和烟碱乙酰胆碱受体活性调节相关的细胞过程，强调了其在细胞生理学和信号传导途径中的潜在重要性。

Immobilized Human PSCA, hFc Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Anti-PSCA Ab., hFc Tag with the EC₅₀ of ≤117.3 ng/mL determined by ELISA.

Human

HEK293

N-hFc

O43653 (L12-S86)

8000  [NCBI]

40-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.