SEMA6D - semaphorin 6D Gene

中文名称：信号素 6D

种属: Homo sapiens

关于 SEMA6D

功能概要

脑信号素是一个大家族，包括分泌蛋白和膜相关蛋白，其中许多在轴突寻路、肌束形成和分支以及目标选择中作为抑制剂或化学驱避剂。所有信号素都在 N 末端细胞外部分具有一个信号素 (Sema) 结构域和一个 PSI 结构域 (在丛蛋白、信号素和整合素中发现) 。信号蛋白域 C 端的附加序列基序允许分类为不同的亚家族。结果表明，跨膜信号蛋白与分泌的信号蛋白一样，可以作为排斥性轴突引导信号。该基因编码 6 类脊椎动物跨膜信号蛋白，该信号蛋白显示选择性剪接。已经确定了几种转录变体，并且认为不同编码亚型的表达以组织和发育依赖性方式进行调节。[RefSeq 提供，2010 年 11 月]

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]