2. Gene
  3. VCPIP1 - valosin containing protein interacting protein 1 Gene

VCPIP1 - valosin containing protein interacting protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 valosin 的蛋白相互作用蛋白 1

种属: Homo sapiens

同用名: DUBA3; VCIP135

基因 ID: 80124 | 基因类型: protein coding

关于 VCPIP1

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,628,487-66,667,231 (from NCBI)

This gene has 1 transcript (splice variant) and 209 orthologues. Ubiquitous expression in bone marrow (RPKM 10.6), spleen (RPKM 6.5) and 25 other tissues.

功能概要

启用硫醇依赖性去泛素化酶。参与蛋白质去泛素化；蛋白质-DNA 共价交联修复；和调节蛋白质定位到染色质。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VCPIP1 基因产物(1)

mRNA Protein Name
NM_025054.5 NP_079330.2 deubiquitinating protein VCPIP1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
23827681 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
32649882 GOA
involved in protein K11-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
involved in protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
32649882 GOA
involved in protein-DNA covalent cross-linking repair IDA
IDA: 通过直接分析推断
32649882 GOA
involved in regulation of protein localization to chromatin IDA
IDA: 通过直接分析推断
32649882 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
32649882 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VCPIP1 蛋白结构

OTU

OTU: OTU-like cysteine protease (215 - 355)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1222 a.a.
蛋白主名 其他名称

deubiquitinating protein VCPIP1

VCP/p47 complex-interacting 135-kDa protein

关联疾病

疾病名称 别名
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158999 VCPIP1-IN-1 99.53% 否
HY-159000 VCPIP1-IN-2 Inhibitor ≥98.0% 否
HY-RS15624 VCPIP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris VCPIP1 VGNC VGNC:48244
Rattus norvegicus VCPIP1 RGD RGD:708520
Felis catus VCPIP1 VGNC VGNC:66934
Macaca mulatta VCPIP1 VGNC VGNC:79895
Mus musculus VCPIP1 MGD MGI:1917925
Others VCPIP1 NCBI
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