2. Gene
  3. NR4A3 - nuclear receptor subfamily 4 group A member 3 Gene

NR4A3 - nuclear receptor subfamily 4 group A member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体亚家族 4 A 组成员 3

种属: Homo sapiens

同用名: CHN; CSMF; NOR1; MINOR

基因 ID: 8013 | 基因类型: protein coding

关于 NR4A3

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,821,885-99,866,891 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 69 phenotypes. Biased expression in adrenal (RPKM 28.0), urinary bladder (RPKM 16.9) and 13 other tissues.

功能概要

该基因编码类固醇-甲状腺激素-类视黄醇受体超家族的成员。编码的蛋白质可以充当转录激活剂。该蛋白可有效结合 NGFI-B 反应元件 (NBRE) 。三种不同版本的骨骼外粘液样软骨肉瘤 (EMC) 是该基因与其他基因相互易位的结果。易位断点与核受体亚科 4、A 组、成员 3 (在 9 号染色体上) 和尤文肉瘤断点区域 1 (在 22 号染色体上) 、RNA 聚合酶 II、TATA 盒结合蛋白相关因子、68-KD 相关 (在 17 号染色体上) ，或转录因子 12 (在 15 号染色体上) 。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 3 月]

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and Other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

NR4A3 基因产物(3)

mRNA Protein Name
NM_006981.4 NP_008912.2 nuclear receptor subfamily 4 group A member 3 isoform a
NM_173199.4 NP_775291.1 nuclear receptor subfamily 4 group A member 3 isoform c
NM_173200.3 NP_775292.1 nuclear receptor subfamily 4 group A member 3 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20558821 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12543801 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
25852083 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
23554459 GOA
involved in positive regulation of D-glucose transmembrane transport IDA
IDA: 通过直接分析推断
24022864 GOA
involved in positive regulation of monocyte aggregation IMP
IMP: 通过突变表型推断
20558821 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20558821 GOA
involved in positive regulation of vascular associated smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
23554459 GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
23554459 GOA
involved in regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
25852083 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NR4A3 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (291 - 359)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (433 - 580)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 626 a.a.
蛋白主名 其他名称

nuclear receptor subfamily 4 group A member 3

chondrosarcoma, extraskeletal myxoid, fused to EWS

NR4A3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NR4A3 Q92570 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
种属内
NR4A3 Q92570 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
种属内
NR4A3 Q92570 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
种属内
NR4A3 Q92570 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
种属内
NR4A3 Q92570 PCSK5 Homo sapiens Q92824-2
Validated Y2H
32296183
种属内
NR4A3 Q92570 KRTAP4-4 Homo sapiens Q9BYR3
Validated Y2H
32296183
种属内
NR4A3 Q92570 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
种属内
NR4A3 Q92570 SMOC1 Homo sapiens Q9H4F8-2
Validated Y2H
32296183
种属内
NR4A3 Q92570 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
种属内
NR4A3 Q92570 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
种属内
NR4A3 Q92570 NECTIN2 Homo sapiens Q92692-2
Validated Y2H
32296183
种属内
NR4A3 Q92570 CHRD Homo sapiens Q9H2X0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma

Emc

Myxoid Extraosseous Chondrosarcoma
Chondrosarcoma

Cartilaginous Cancer

Chondrosarcoma Of Bone

Primary Chondrosarcoma Of The Bone

CHDSA
Myxoid Chondrosarcoma
Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Vulvar Sarcoma

Sarcoma Of Vulva

Vulva Sarcoma
Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Parachordoma
Bone Chondrosarcoma
Acinar Cell Carcinoma

Acinic Cell Carcinoma

Acinic Cell Tumor

Carcinoma Acinar Cell

Carcinoma, Acinar Cell

Acinar Cell Tumor
Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland

Sweat Gland Tumor

Tumor Of The Sweat Gland

Sweat Gland Neoplasms

Sweat Gland Neoplasm
Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma
Bone Sarcoma
Myxofibrosarcoma

Fibromyxosarcoma

Fibromyxoid Sarcoma

Myxoid Malignant Fibrous Histiocytoma

Dermatofibrosarcoma Protuberans, Myxoid
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09552 NR4A3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NR4A3 VGNC VGNC:32247
Macaca mulatta NR4A3 VGNC VGNC:75519
Felis catus NR4A3 VGNC VGNC:68556
Rattus norvegicus NR4A3 RGD RGD:61882
Mus musculus NR4A3 MGD MGI:1352457
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