2. Gene
  3. ORAI2 - ORAI calcium release-activated calcium modulator 2 Gene

ORAI2 - ORAI calcium release-activated calcium modulator 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ORAI 钙释放激活钙调节因子 2

种属: Homo sapiens

同用名: CBCIP2; C7orf19; MEM142B; TMEM142B

基因 ID: 80228 | 基因类型: protein coding

关于 ORAI2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,433,575-102,456,825 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 2 paralogues. Broad expression in spleen (RPKM 5.4), bone marrow (RPKM 5.3) and 23 other tissues.

功能概要

预计会启用存储操作的钙通道活动。预计将参与商店经营的钙进入。预计位于生长锥内。预计是膜的组成部分。预测在膜中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable store-operated Calcium Channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in growth cone. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ORAI2 基因产物(4)

mRNA Protein Name
NM_001126340.3 NP_001119812.1 protein orai-2 isoform a
NM_001271818.2 NP_001258747.1 protein orai-2 isoform a
NM_001271819.2 NP_001258748.1 protein orai-2 isoform b
NM_032831.4 NP_116220.1 protein orai-2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17442569 GOA
enables store-operated calcium channel activity IDA
IDA: 通过直接分析推断
17442569 GOA
enables store-operated calcium channel activity IMP
IMP: 通过突变表型推断
32415068 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in store-operated calcium entry IDA
IDA: 通过直接分析推断
19182790 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
32415068 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ORAI2 蛋白结构

Orai-1

Orai-1: Mediator of CRAC channel activity (42 - 230)

  • 0
  • 100
  • 200
  • 254 a.a.
蛋白主名 其他名称

protein orai-2

CAP-binding protein complex interacting protein 2

关联疾病

疾病名称 别名
Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2

Combined Immunodeficiency Due To Stim1 Deficiency

IMD10

Stim1 Deficiency

Cid Due To Stim1 Deficiency

Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2

Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Amelogenesis Imperfecta, Type Iiia

Ai3

Adhcai

Amelogenesis Imperfecta Type 3

AI3A

Amelogenesis Imperfecta, Type Iii

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant

Amelogenesis Imperfecta Type 3a

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iii

Hypocalcified Amelogenesis Imperfecta

Amelogenesis Imperfecta, Type 3

Amelogenesis Imperfecta, Hypomineralization Type

Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3a

Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis

Stormorken-Sjaastad-Langslet Syndrome

STRMK

York Platelet Syndrome

Yps

Thrombocytopathy, Asplenia And Miosis

Thrombocytopathy Asplenia Miosis

Thrombocytopathy-Asplenia-Miosis Syndrome

Miosis Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-101942 Zegocractin Inhibitor 99.96% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09823 ORAI2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ORAI2 MGD MGI:2443195
Felis catus ORAI2 VGNC VGNC:63972
Macaca mulatta ORAI2 VGNC VGNC:75665
Rattus norvegicus ORAI2 RGD RGD:1310213
Canis familiaris ORAI2 VGNC VGNC:44138
Bos taurus ORAI2 VGNC VGNC:32444
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