2. Gene
  3. EPC1 - enhancer of polycomb homolog 1 Gene

EPC1 - enhancer of polycomb homolog 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：多梳同系物 1 的增强子

种属: Homo sapiens

同用名: Epl1

基因 ID: 80314 | 基因类型: protein coding

关于 EPC1

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,267,751-32,378,769 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 17.1), ovary (RPKM 10.0) and 25 other tissues.

功能概要

该基因编码多梳组 (PcG) 家族的成员。编码的蛋白质是 NuA4 组蛋白乙酰转移酶复合物的一个组成部分，可以作为转录激活剂和阻遏物。编码的蛋白质与细胞凋亡、DNA 修复、骨骼肌分化、基因沉默和成人 T 细胞白血病/淋巴瘤有关。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 Histone Acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to Apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

EPC1 基因产物(8)

mRNA Protein Name
NM_001272004.3 NP_001258933.1 enhancer of polycomb homolog 1 isoform b
NM_001272019.4 NP_001258948.1 enhancer of polycomb homolog 1 isoform c
NM_001282391.3 NP_001269320.1 enhancer of polycomb homolog 1 isoform d
NM_001382753.1 NP_001369682.1 enhancer of polycomb homolog 1 isoform e
NM_001382754.1 NP_001369683.1 enhancer of polycomb homolog 1 isoform f
NM_001382755.1 NP_001369684.1 enhancer of polycomb homolog 1 isoform g
NM_001382756.1 NP_001369685.1 enhancer of polycomb homolog 1 isoform h
NM_025209.5 NP_079485.1 enhancer of polycomb homolog 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin-protein adaptor activity IDA
IDA: 通过直接分析推断
32209463 GOA
enables enzyme-substrate adaptor activity IDA
IDA: 通过直接分析推断
28694333 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
27153538 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10976108 GOA
acts upstream of or within negative regulation of gene expression, epigenetic IDA
IDA: 通过直接分析推断
10976108 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10976108 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
27153538 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10976108 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
27153538 GOA
involved in sperm DNA condensation IMP
IMP: 通过突变表型推断
28694333 GOA
involved in spermatid development IMP
IMP: 通过突变表型推断
28694333 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NuA4 histone acetyltransferase complex IDA
IDA: 通过直接分析推断
14966270 GOA
located in nuclear membrane IDA
IDA: 通过直接分析推断
10976108 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
10976108 GOA
part of nucleosome IDA
IDA: 通过直接分析推断
27153538 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10976108 GOA
part of piccolo histone acetyltransferase complex IDA
IDA: 通过直接分析推断
14966270 GOA
is active in site of double-strand break IDA
IDA: 通过直接分析推断
27153538 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EPC1 蛋白结构

EPL1

EPL1: Enhancer of polycomb-like (6 - 148)

E_Pc_C

E_Pc_C: Enhancer of Polycomb C-terminus (582 - 836)

  • 0
  • 200
  • 400
  • 600
  • 836 a.a.
蛋白主名 其他名称

enhancer of polycomb homolog 1

EPC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EPC1 Q9H2F5 MBTD1 Homo sapiens Q05BQ5
Anti Tag CoIP
27153538
种属内
EPC1 Q9H2F5 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
25416956
种属内
EPC1 Q9H2F5 RINT1 Homo sapiens Q6NUQ1
Y2H Array
31515488
种属内
EPC1 Q9H2F5 RINT1 Homo sapiens Q6NUQ1
Y2H Array
25416956
种属内
EPC1 Q9H2F5 KRT15 Homo sapiens P19012
Y2H Array
25416956
种属内
EPC1 Q9H2F5 BRD8 Homo sapiens Q9H0E9
Anti Tag CoIP
27153538
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia
Apolipoprotein C-Iii Deficiency

Hyperalphalipoproteinemia 2

HALP2
Noonan Syndrome 11

NS11
Noonan Syndrome 8

NS8

Noonan Syndrome, Type 8
Noonan Syndrome 4

NS4

Noonan Syndrome, Type 4
Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04418 EPC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus EPC1 MGD MGI:1278322
Bos taurus EPC1 VGNC VGNC:28527
Macaca mulatta EPC1 VGNC VGNC:72074
Felis catus EPC1 VGNC VGNC:61898
Canis familiaris EPC1 VGNC VGNC:40400
Rattus norvegicus EPC1 RGD RGD:2324280
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