ULBP2 - UL16 binding protein 2 Gene

中文名称：UL16 结合蛋白 2

种属: Homo sapiens

同用名: N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha

关于 ULBP2

功能概要

该基因编码主要组织相容性复合体 (MHC) I 类相关分子，该分子与自然杀伤 (NK) 细胞上的 NKG2D 受体结合，触发多种细胞因子和趋化因子的释放，进而促进 NK 细胞的募集和激活。编码的蛋白质经过进一步加工以生成成熟蛋白质，该蛋白质要么通过糖基磷脂酰肌醇部分锚定到膜上，要么被分泌。许多恶性细胞分泌编码的蛋白质以逃避 NK 细胞的免疫监视。该基因位于 6 号染色体上的多个 MHC I 类相关基因簇中。[RefSeq 提供，2015 年 7 月]

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]