2. Gene
  3. DCAF11 - DDB1 and CUL4 associated factor 11 Gene

DCAF11 - DDB1 and CUL4 associated factor 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DDB1 和 CUL4 相关因子 11

种属: Homo sapiens

同用名: GL014; WDR23; PRO2389

基因 ID: 80344 | 基因类型: protein coding

关于 DCAF11

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,114,777-24,125,242 (from NCBI)

This gene has 38 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in liver (RPKM 25.7), small intestine (RPKM 25.5) and 25 other tissues.

功能概要

该基因编码一种含有 WD 重复序列的蛋白质，该蛋白质与 COP9 信号体相互作用，COP9 信号体是一种大分子复合物，可与 cullin-RING E3 连接酶相互作用并通过水解 cullin-Nedd8 结合物来调节其活性。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2009 年 7 月]

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 Ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

DCAF11 基因产物(3)

mRNA Protein Name
NM_001163484.2 NP_001156956.1 DDB1- and CUL4-associated factor 11 isoform 1
NM_025230.5 NP_079506.3 DDB1- and CUL4-associated factor 11 isoform 1
NM_181357.2 NP_852002.1 DDB1- and CUL4-associated factor 11 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16949367 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16949367 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCAF11 蛋白结构

WD40

WD40: WD domain, G-beta repeat (304 - 336)

WD40

WD40: WD domain, G-beta repeat (346 - 383)

WD40

WD40: WD domain, G-beta repeat (475 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 546 a.a.
蛋白主名 其他名称

DDB1- and CUL4-associated factor 11

WD repeat domain 23

DCAF11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCAF11 Q8TEB1 GPSM1 Homo sapiens Q86YR5-3
Y2H Array
32296183
Intra DCAF11 Q8TEB1 GPSM1 Homo sapiens Q86YR5-3
Y2H Prey Pooling
32296183
Intra DCAF11 Q8TEB1 DDB1 Homo sapiens Q16531
Anti Tag CoIP
28514442
Intra DCAF11 Q8TEB1 DDB1 Homo sapiens Q16531
Anti Tag CoIP
33961781
Intra DCAF11 Q8TEB1 DDB1 Homo sapiens Q16531
Pull Down
19109893
Intra DCAF11 Q8TEB1 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra DCAF11 Q8TEB1 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra DCAF11 Q8TEB1 TNNI1 Homo sapiens P19237
Y2H Array
32296183
Intra DCAF11 Q8TEB1 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
Intra DCAF11 Q8TEB1 TNNI2 Homo sapiens P48788
Y2H Prey Pooling
32296183
Intra DCAF11 Q8TEB1 TNNI2 Homo sapiens P48788
Y2H Array
32296183
Intra DCAF11 Q8TEB1 RCN1 Homo sapiens Q15293
Y2H Prey Pooling
32296183
Intra DCAF11 Q8TEB1 RCN1 Homo sapiens Q15293
Y2H Array
32296183
Cross DCAF11 Q8TEB1 vif Human immunodeficiency virus P12504
Pull Down
22190034
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Loeys-Dietz Syndrome 1

Furlong Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome

LDS1

Aat5

Loeys-Dietz Syndrome Type 1

Aortic Aneurysm, Familial Thoracic 5

Familial Throacic Aortic Aneurysm 5

Loeys-Dietz Syndrome

Aortic Aneurysm Syndrome, Loeys-Dietz Type

Familial Thoracic Aortic Aneurysm 5

Ldas

Marfanoid Disorder-Craniosynostosis Syndrome

Aneurysm, Aortic, Thoracic, Familial, Type 5

Loeys-Dietz Syndrome, Type 1

Loeys-Dietz Syndrome, Type 2a
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158764 PROTAC BET Degrader-12 Degrader 98.10% 否
HY-161779 PLX-3618 / 否
HY-169358 L134 Inhibitor / 否
HY-RS03558 DCAF11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DCAF11 VGNC VGNC:97258
Felis catus DCAF11 VGNC VGNC:80991
Mus musculus DCAF11 MGD MGI:90168
Rattus norvegicus DCAF11 RGD RGD:1311288
Macaca mulatta DCAF11 VGNC VGNC:84330
Canis familiaris DCAF11 VGNC VGNC:57371
Others DCAF11 NCBI
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