NDFIP1 - Nedd4 family interacting protein 1 Gene

中文名称：Nedd4 家族相互作用蛋白 1

种属: Homo sapiens

同用名: N4WBP5

基因 ID: 80762 | 基因类型: protein coding

关于 NDFIP1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,108,779-142,154,440 (from NCBI)

This gene has 4 transcripts (splice variants), 280 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 106.7), thyroid (RPKM 68.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于一小组进化上保守的蛋白质，具有三个跨膜结构域。它是 Nedd4 蛋白家族泛素化的潜在目标。这种蛋白质被认为是完整的高尔基体膜蛋白家族的一部分。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

NDFIP1 基因产物(1)

mRNA	Protein	Name
NM_030571.4	NP_085048.1	NEDD4 family-interacting protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18776082	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intracellular iron ion homeostasis	IMP IMP: 通过突变表型推断	18776082	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	18776082	GOA
involved in negative regulation of protein transport	IMP IMP: 通过突变表型推断	18776082	GOA
involved in negative regulation of transporter activity	IMP IMP: 通过突变表型推断	18776082	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	25631046	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	18776082	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	18776082	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDFIP1 蛋白结构

DUF2370

0
100
200
221 a.a.

蛋白主名

其他名称

NEDD4 family-interacting protein 1

Nedd4 WW domain-binding protein 5

NDFIP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NDFIP1	Q9BT67	SLC11A2	Homo sapiens	P49281	Anti Bait CoIP	19706893

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Congenital Myasthenic Syndrome 7

Cms7	Congenital Myasthenic Syndrome 7 Presynaptic
Myasthenic Syndrome, Congenital, Type 7, Presynaptic

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09108	NDFIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NDFIP1	VGNC	VGNC:63750
Canis familiaris	NDFIP1	VGNC	VGNC:43673
Rattus norvegicus	NDFIP1	RGD	RGD:1310053
Bos taurus	NDFIP1	VGNC	VGNC:31934
Mus musculus	NDFIP1	MGD	MGI:1929601
Macaca mulatta	NDFIP1	VGNC	VGNC:74979

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NDFIP1 - Nedd4 family interacting protein 1 Gene

关于 NDFIP1

功能概要

NDFIP1 基因产物(1)

NDFIP1 蛋白结构

NDFIP1 蛋白互作信息

关联疾病

直系同源

热门区域

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NDFIP1 - Nedd4 family interacting protein 1 Gene

关于 NDFIP1

功能概要

NDFIP1 基因产物(1)

NDFIP1 蛋白结构

NDFIP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z