2. Gene
  3. CALM3 - calmodulin 3 Gene

CALM3 - calmodulin 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙调蛋白 3

种属: Homo sapiens

同用名: CaM; CALM; CAM1; CAM2; CAMB; PHKD; CPVT6; LQT16; PHKD3; CaMIII; HEL-S-72

基因 ID: 808 | 基因类型: protein coding

关于 CALM3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,601,074-46,610,782 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues, 20 paralogues and is associated with 5 phenotypes. Ubiquitous expression in brain (RPKM 470.4), testis (RPKM 108.1) and 23 other tissues.

功能概要

该基因编码一个蛋白质家族的成员，该蛋白质家族可结合钙并作为酶促辅因子发挥作用。这种蛋白质的活性在细胞周期和胞质分裂的调节中很重要。已在该基因上观察到多个选择性剪接的转录物变体。[RefSeq 提供，2016 年 8 月]

This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

CALM3 基因产物(7)

mRNA Protein Name
NM_001329921.1 NP_001316850.1 calmodulin-3 isoform 2
NM_001329922.1 NP_001316851.1 calmodulin-3 isoform 1
NM_001329923.1 NP_001316852.1 calmodulin-3 isoform 2
NM_001329924.2 NP_001316853.1 calmodulin-3 isoform 2
NM_001329925.2 NP_001316854.1 calmodulin-3 isoform 2
NM_001329926.2 NP_001316855.1 calmodulin-3 isoform 2
NM_005184.4 NP_005175.2 calmodulin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenylate cyclase activator activity IDA
IDA: 通过直接分析推断
11807546 GOA
enables adenylate cyclase binding IPI
IPI: 通过物理相互作用推断
11807546 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
7607248 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
3111527 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein phosphatase activator activity IDA
IDA: 通过直接分析推断
8631777 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
35568036 GOA
enables titin binding IPI
IPI: 通过物理相互作用推断
7607248 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
21167176 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in detection of calcium ion IMP
IMP: 通过突变表型推断
23040497 GOA
involved in negative regulation of high voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
31454269 GOA
involved in positive regulation of cyclic-nucleotide phosphodiesterase activity IDA
IDA: 通过直接分析推断
8631777 GOA
involved in positive regulation of ryanodine-sensitive calcium-release channel activity IDA
IDA: 通过直接分析推断
20226167 GOA
involved in regulation of cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
31454269 GOA
involved in regulation of cardiac muscle contraction IMP
IMP: 通过突变表型推断
23040497 GOA
involved in regulation of cytokinesis IMP
IMP: 通过突变表型推断
16760425 GOA
involved in regulation of heart rate IMP
IMP: 通过突变表型推断
23040497 GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
20226167 GOA
involved in response to calcium ion IDA
IDA: 通过直接分析推断
7607248 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium channel complex IDA
IDA: 通过直接分析推断
23040497 GOA
part of catalytic complex IDA
IDA: 通过直接分析推断
11807546 GOA
located in centrosome IDA
IDA: 通过直接分析推断
16760425 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
19855925 GOA
located in sarcomere IDA
IDA: 通过直接分析推断
20226167 GOA
located in spindle microtubule IDA
IDA: 通过直接分析推断
16760425 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
16760425 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CALM3 蛋白结构

EF-hand_7

EF-hand_7: EF-hand domain pair (14 - 73)

EF-hand_7

EF-hand_7: EF-hand domain pair (86 - 146)

  • 0
  • 100
  • 149 a.a.
蛋白主名 其他名称

calmodulin-3

Calmodulin-1

重组 CALM3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7710 Calmodulin Protein, Human P0DP23 (M1-K149) ≥95%
HY-P75461 CALM2 Protein, Human (His) P0DP24 (M1-K149) ≥95%

关联疾病

疾病名称 别名
Long Qt Syndrome 16

Ventricular Tachycardia, Catecholaminergic Polymorphic, 6

LQT16

Ventricular Tachycardia, Catecholaminergic Polymorphic 6

CPVT6
Long Qt Syndrome 1

Romano-Ward Syndrome

LQT1

Ward-Romano Syndrome

Rws

Ventricular Fibrillation With Prolonged Qt Interval

Wrs

Long Qt Syndrome 1, Acquired, Susceptibility To

Long Qt Syndrome 1, Acquired

Romano-Ward Long Qt Syndrome

Long Qt Syndrome Type 1

Long Qt Syndrome-1

Acquired Susceptibility To Long Qt Syndrome 1

Qt Syndrome, Long, Type 1
Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt

Catecholamine-Induced Polymorphic Ventricular Tachycardia

Familial Polymorphic Ventricular Tachycardia

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Stress-Induced Polymorphic Ventricular Tachycardia

Bidirectional Tachycardia Induced By Catecholamine

Double Tachycardia Induced By Catecholamines

Polymorphic Catecholergic Ventricular Tachycardia

Syncopal Paroxysmal Tachycardia

Bidirectional Tachycardia Induced By Catecholamines

Fpvt

Bidirectional Ventricular Tachycardia Induced By Catecholamine

Polymorphic Ventricular Tachycardia Induced By Catecholamines

Ventricular Tachycardia, Catecholaminergic Polymorphic

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Familial Ventricular Tachycardia

Multifocal Pvcs

Multifocal Premature Ventricular Beats
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Long Qt Syndrome 14

LQT14

Long Qt Syndrome, Type 14
Long Qt Syndrome 15

LQT15

Long Qt Syndrome, Type 15
Cardiac Arrest

Cardiopulmonary Arrest

Circulatory Arrest

Heart Arrest
Flying Phobia

Aerophobia
Medulloblastoma Shh Activated And Tp53 Mutant
Diamond-Blackfan Anemia 3

DBA3

Anemia, Diamond-Blackfan, 3

Rps24-Related Diamond-Blackfan Anemia

Anemia Diamond-Blackfan 3

Anemia, Diamond-Blackfan, Type 3
Medulloblastoma Non-Wnt/Non-Shh
Long Qt Syndrome 2

LQT2

Long Qt Syndrome, Acquired, Reduced Susceptibility To

Long Qt Syndrome 1/2

Long Qt Syndrome 2/3

Long Qt Syndrome 2/5

Long Qt Syndrome 2, Acquired, Susceptibility To

Long Qt Syndrome, Acquired, Reduced

Long Qt Syndrome Type 2

Long Qt Syndrome 2/9

Lqt1/2

Lqt2/3

Lqt2/5

Lqt2/9

Susceptibility To Acquired Long Qt Syndrome 2

Long Qt Syndrome-2

Qt Syndrome, Long, Type 2

Long Qt Syndrome 1-2

Long Qt Syndrome 2-3

Long Qt Syndrome 2-5

Long Qt Syndrome 9
Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease
Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome

Sudden Unexplained Nocturnal Death Syndrome

Bangungut

Brugada Type Idiopathic Ventricular Fibrillation

Pokkuri Death Syndrome

Sunds

Idiopathic Ventricular Fibrillation, Brugada Type

Sudden Unexplained Death

Dream Disease

Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

Sudden Unexplained Death Syndrome

Suds

Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01842 CALM3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CALM3 MGD MGI:103249
Rattus norvegicus CALM3 RGD RGD:2259
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