2. Gene
  3. CAMK4 - calcium/calmodulin dependent protein kinase IV Gene

CAMK4 - calcium/calmodulin dependent protein kinase IV Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙/钙调蛋白依赖性蛋白激酶 IV

种属: Homo sapiens

同用名: caMK; CaMKIV; CaMK IV; CaMK-GR

基因 ID: 814 | 基因类型: protein coding

关于 CAMK4

Cytogenetic location: 5q22.1 Genomic coordinates (GRCh38): 5:111,223,583-111,494,886 (from NCBI)

This gene has 13 transcripts (splice variants), 173 orthologues and 6 paralogues. Broad expression in brain (RPKM 7.0), lymph node (RPKM 3.7) and 21 other tissues.

功能概要

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族，以及 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族。这种酶是一种多功能丝氨酸/苏氨酸蛋白激酶，组织分布有限，与淋巴细胞、神经元和雄性生殖细胞的转录调节有关。[RefSeq 提供，2008 年 7 月]

The product of this gene belongs to the serine/threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. This Enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

CAMK4 基因产物(5)

mRNA Protein Name
NM_001323374.2 NP_001310303.1 calcium/calmodulin-dependent protein kinase type IV isoform 1
NM_001323375.2 NP_001310304.1 calcium/calmodulin-dependent protein kinase type IV isoform 1
NM_001323376.2 NP_001310305.1 calcium/calmodulin-dependent protein kinase type IV isoform 2
NM_001323377.2 NP_001310306.1 calcium/calmodulin-dependent protein kinase type IV isoform 2
NM_001744.6 NP_001735.1 calcium/calmodulin-dependent protein kinase type IV isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: 通过直接分析推断
8107230 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in long-term memory IGI
IGI: 通过遗传相互作用推断
18829949 GOA
involved in myeloid dendritic cell differentiation IMP
IMP: 通过突变表型推断
17909078 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8855261 GOA
NOT involved in positive regulation of myeloid dendritic cell cytokine production IMP
IMP: 通过突变表型推断
17909078 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAMK4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (46 - 300)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type IV

CAM kinase IV

CAMK4 抗体

目录号 产品名 应用 反应物种
HY-P81263 CAMKIV Antibody (YA942) WB Human
HY-P81263A CAMKIV Antibody (YA943) WB, IHC-P, ICC/IF, IP, FC Human

关联疾病

疾病名称 别名
Cerebral Hypoxia

Brain Hypoxia
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01864 CAMK4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CAMK4 RGD RGD:2264
Bos taurus CAMK4 VGNC VGNC:106668
Canis familiaris CAMK4 VGNC VGNC:53157
Felis catus CAMK4 VGNC VGNC:60335
Macaca mulatta CAMK4 VGNC VGNC:70526
Mus musculus CAMK4 MGD MGI:88258
Others CAMK4 NCBI
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