1. Gene
  2. TMX1 - thioredoxin related transmembrane protein 1 Gene

TMX1 - thioredoxin related transmembrane protein 1 Gene

中文名称:硫氧还蛋白相关跨膜蛋白 1

种属: Homo sapiens

同用名: TMX; TXNDC; PDIA11; TXNDC1

基因 ID: 81542 | 基因类型: protein coding

关于 TMX1

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,240,247-51,257,655 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 13 paralogues. Ubiquitous expression in urinary bladder (RPKM 15.6), colon (RPKM 14.8) and 25 other tissues.

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员,该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有一个 N 端 ER 信号序列、一个具有催化活性的硫氧还蛋白结构域和一个跨膜结构域。与该基因家族的大多数成员不同,它缺少 C 端 ER 保留序列。成熟的膜结合蛋白可以氧化和还原二硫键,并选择性地作用于膜相关多肽。[RefSeq 提供,2017 年 1 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

TMX1 基因产物(1)

mRNA Protein Name
NM_030755.5 NP_110382.3 thioredoxin-related transmembrane protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables disulfide oxidoreductase activity IDA
IDA: 通过直接分析推断
11152479 GOA
enables enzyme inhibitor activity IDA
IDA: 通过直接分析推断
37648867 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein disulfide isomerase activity IDA
IDA: 通过直接分析推断
29932915 GOA
enables protein-disulfide reductase activity IDA
IDA: 通过直接分析推断
22228764 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of platelet aggregation IDA
IDA: 通过直接分析推断
30425049 GOA
involved in negative regulation of triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
37648867 GOA
involved in positive regulation of ERAD pathway IDA
IDA: 通过直接分析推断
29932915 GOA
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
27502484 GOA
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
11152479 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
37648867 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
11152479 GOA
is active in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
22045338 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMX1 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (31 - 129)

  • 0
  • 100
  • 200
  • 280 a.a.
蛋白主名 其他名称

thioredoxin-related transmembrane protein 1

protein disulfide isomerase family A, member 11

重组 TMX1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76681 TMX1 Protein, Human (HEK293, Fc) AAH36460 (R27-S180) ≥95%

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TMX1 VGNC VGNC:47643
Mus musculus TMX1 MGD MGI:1919986
Rattus norvegicus TMX1 RGD RGD:1308455
Macaca mulatta TMX1 VGNC VGNC:103880
Bos taurus TMX1 VGNC VGNC:50016
Others TMX1 NCBI