LMAN2L - lectin, mannose binding 2 like Gene

中文名称：凝集素、甘露糖结合 2 样

种属: Homo sapiens

同用名: VIPL; MRD69; MRT52

关于 LMAN2L

功能概要

该基因编码的蛋白质属于 1 型膜蛋白的 L 型凝集素组，在哺乳动物早期分泌途径中起作用。这些蛋白质包含管腔碳水化合物识别域，显示与豆科植物凝集素的同源性。与该组中在早期分泌途径中循环并主要与内质网后膜相关的其他蛋白质不同，由该基因编码的蛋白质是 ER 的非循环常驻蛋白，它在其中充当糖蛋白的货物受体.建议调节折叠蛋白的交换以转运至高尔基体和错误折叠的糖蛋白的交换以转运至泛素-蛋白酶体途径。[RefSeq 提供，2016 年 4 月]

This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike Other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]