2. Gene
  3. PPP1R14C - protein phosphatase 1 regulatory inhibitor subunit 14C Gene

PPP1R14C - protein phosphatase 1 regulatory inhibitor subunit 14C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 1 调节抑制因子亚基 14C

种属: Homo sapiens

同用名: KEPI; NY-BR-81; CPI17-like

基因 ID: 81706 | 基因类型: protein coding

关于 PPP1R14C

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:150,143,044-150,250,392 (from NCBI)

This gene has 1 transcript (splice variant), 113 orthologues and 3 paralogues. Biased expression in thyroid (RPKM 22.2), heart (RPKM 17.2) and 9 other tissues.

功能概要

蛋白质磷酸化的程度受蛋白激酶和磷酸酶活性平衡的调节。蛋白磷酸酶 1 (PP1；参见 MIM 176875) 是一种信号转导磷酸酶，可影响神经元活动、蛋白质合成、新陈代谢、肌肉收缩和细胞分裂。 PPP1R14C 是 PP1 的抑制剂 (Liu 等人，2002 [PubMed 11812771]) 。[OMIM 提供，2010 年 2 月]

The degree of protein phosphorylation is regulated by a balance of protein kinase and Phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing Phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

PPP1R14C 基因产物(1)

mRNA Protein Name
NM_030949.3 NP_112211.1 protein phosphatase 1 regulatory subunit 14C

PPP1R14C 蛋白结构

PP1_inhibitor

PP1_inhibitor: PKC-activated protein phosphatase-1 inhibitor (51 - 162)

  • 0
  • 100
  • 165 a.a.
蛋白主名 其他名称

protein phosphatase 1 regulatory subunit 14C

PKC-potentiated PP1 inhibitory protein

关联疾病

疾病名称 别名
Ophthalmomyiasis

Ocular Myiasis

Ophthalmic Myiasis

Myiasis Oestruosa
Thyroid Dyshormonogenesis 4

Deiodinase Deficiency

TDH4

Iodotyrosine Dehalogenase Deficiency

Thyroid Hormonogenesis, Genetic Defect In, 4

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4

Genetic Defect In Thyroid Hormonogenesis 4

Chdh4

Congenital Hypothyroidism Due To Dyshormonogenesis Type 4

Genetic Defect In Thyroid Hormonogenesis Type 4
Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter
Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9

ALS9

Sclerosis, Lateral, Amyotrophic, Type Type 9
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10985 PPP1R14C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PPP1R14C VGNC VGNC:76261
Mus musculus PPP1R14C MGD MGI:1923392
Rattus norvegicus PPP1R14C RGD RGD:620538
Felis catus PPP1R14C VGNC VGNC:102488
Bos taurus PPP1R14C VGNC VGNC:33227
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