2. Gene
  3. Tgfb2 - transforming growth factor, beta 2 Gene

Tgfb2 - transforming growth factor, beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：转化生长因子， β 2

种属: Rattus norvegicus

同用名: TGF-B2

基因 ID: 81809 | 基因类型: protein coding

关于 Tgfb2

Primary_assembly 13: 98,160,087-98,261,405 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 199 orthologues, 31 paralogues and is associated with 45 phenotypes. Biased expression in Lung (RPKM 13.), Muscle (RPKM 77.3) and 9 other tissues.

功能概要

实现相同的蛋白质结合活性和蛋白质 N 末端结合活性。参与多个过程，包括动物器官发育；螯合钙离子释放到胞质溶胶中的负调节；和细胞凋亡过程的调节。位于多种细胞成分中，包括基底膜；分泌颗粒;和跨高尔基网络。糖尿病神经病变的生物标志物；心肌梗塞;和骨软骨发育不良。该基因的人类直系同源物与 Loeys-Dietz 综合征 4 和结直肠癌有关。与人 TGFB2（转化生长因子 β 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Located in several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal Cancer. Orthologous to human TGFB2 (transforming growth factor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb2 基因产物(1)

mRNA Protein Name
NM_031131.2 NP_112393.2 transforming growth factor beta-2 proprotein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18406405 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18406405 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in digestive tract development IEP
IEP: 通过表达模式推断
12815632 RGD
involved in embryonic neurocranium morphogenesis IDA
IDA: 通过直接分析推断
11002343 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
15927076 RGD
involved in frontal suture morphogenesis IEP
IEP: 通过表达模式推断
12416537 RGD
involved in hindbrain development IEP
IEP: 通过表达模式推断
11231055 RGD
involved in inner ear development IEP
IEP: 通过表达模式推断
16479080 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
11245570 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
11002343 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15944186 RGD
involved in negative regulation of release of sequestered calcium ion into cytosol IDA
IDA: 通过直接分析推断
12876066 RGD
involved in pancreas development IEP
IEP: 通过表达模式推断
16479313 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
16532270 RGD
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
11014222 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11002343 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
15899155 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
15746252 RGD
involved in response to estrogen IDA
IDA: 通过直接分析推断
12130550 RGD
involved in response to laminar fluid shear stress IEP
IEP: 通过表达模式推断
16217485 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
16479313 RGD
involved in response to vitamin D IEP
IEP: 通过表达模式推断
11956143 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15746252 RGD
involved in skeletal muscle tissue development IEP
IEP: 通过表达模式推断
16439574 RGD
involved in thyroid gland development IEP
IEP: 通过表达模式推断
18554691 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
16479080 RGD
located in cell surface IDA
IDA: 通过直接分析推断
12595240 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
12595240 RGD
located in secretory granule IDA
IDA: 通过直接分析推断
12595240 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
12595240 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tgfb2 蛋白结构

TGFb_propeptide

TGFb_propeptide: pfam00688 (20 - 255)

TGF_beta_TGFB2

TGF_beta_TGFB2: cd19385 (344 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
蛋白主名 其他名称

transforming growth factor beta-2 proprotein

TGF beta 2 protein

TGF-beta-2

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990009 Nisevokitug Inhibitor 97.00% Phase 3
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14439 TGFB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14440 Tgfb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14441 Tgfb2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tgfb2 NCBI NCBI:7042
Canis familiaris Tgfb2 NCBI NCBI:488596
Mus musculus Tgfb2 NCBI NCBI:21808
Macaca mulatta Tgfb2 NCBI NCBI:707540
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