Tgfb2 - transforming growth factor, beta 2 Gene

中文名称：转化生长因子， β 2

种属: Mus musculus

同用名: Tgfb-2; Tgf-beta2

关于 Tgfb2

功能概要

该基因编码 TGF-β（转化生长因子-β）蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理以生成潜伏相关肽 (LAP) 和成熟肽，并且以由成熟肽同二聚体、LAP 同二聚体和潜伏 TGF-β 结合蛋白组成的潜伏形式被发现，或者以仅由成熟肽同源二聚体组成的活性形式存在。成熟肽还可以与其他 TGF-β 家族成员形成异二聚体。缺乏该基因功能拷贝的小鼠在多个器官和围产期致死率方面表现出发育缺陷。杂合突变小鼠表现出主动脉根部动脉瘤。该基因编码可能经历类似蛋白水解加工的多种亚型。 [RefSeq 提供，2016 年 8 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]