1. Gene
  2. Sh3gl1 - SH3 domain containing GRB2 like 1, endophilin A2 Gene

Sh3gl1 - SH3 domain containing GRB2 like 1, endophilin A2 Gene

种属: Rattus norvegicus

同用名: SH3P8

基因 ID: 81922 | 基因类型: protein coding

关于 Sh3gl1

功能概要

Enables several functions, including SH3 domain binding activity; beta-1 Adrenergic Receptor binding activity; and Enzyme binding activity. Involved in modulation of excitatory postsynaptic potential and positive regulation of synaptic vesicle endocytosis. Located in membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Used to study high grade glioma. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl1 基因产物(1)

mRNA Protein Name
NM_031239.3 NP_112518.1 endophilin-A2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase binding IPI
IPI: 通过物理相互作用推断
9238017 RGD
enables SH3 domain binding IMP
IMP: 通过突变表型推断
22750032 RGD
enables beta-1 adrenergic receptor binding IMP
IMP: 通过突变表型推断
22750032 RGD
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
9238017 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11498538 RGD
enables transmembrane transporter binding IMP
IMP: 通过突变表型推断
22750032 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
22961472 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in modulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
22750032 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
14532001 RGD
involved in regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
22750032 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
11518713 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17088211 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
11518713 RGD
located in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
11518713 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
17088211 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
17088211 RGD
is active in synapse IDA
IDA: 通过直接分析推断
11518713 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

endophilin-A2

SH3 domain protein 2B

SH3 domain-containing GRB2-like 1

SH3 domain-containing GRB2-like protein 1

SH3-domain GRB2-like 1

endophilin-2

Sh3gl1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Sh3gl1 O35964 RAPH1 Homo sapiens Q70E73
Far-WB
24076656
种属间
Sh3gl1 O35964 RAPH1 Homo sapiens Q70E73
Peptide Array
24076656
种属间
Sh3gl1 O35964 RAPH1 Homo sapiens Q70E73
Pull Down
24076656
种属间
Sh3gl1 O35964 RAPH1 Homo sapiens Q70E73
IF
24076656
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sh3gl1 NCBI NCBI:6455