2. Gene
  3. CHAF1B - chromatin assembly factor 1 subunit B Gene

CHAF1B - chromatin assembly factor 1 subunit B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：染色质装配因子 1 亚基 B

种属: Homo sapiens

同用名: CAF1; MPP7; CAF-1; CAF1A; CAF1P60; CAF-IP60; MPHOSPH7

基因 ID: 8208 | 基因类型: protein coding

关于 CHAF1B

Cytogenetic location: 21q22.12-q22.13 Genomic coordinates (GRCh38): 21:36,385,392-36,419,015 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Broad expression in bone marrow (RPKM 2.7), testis (RPKM 2.6) and 25 other tissues.

功能概要

组蛋白八聚体组装到新复制的 DNA 上需要染色质组装因子 I (CAF-I) 。 CAF-I 由三个蛋白质亚基 p50、p60 和 p150 组成。该基因编码的蛋白质对应于 p60 亚基，是复制后染色质组装所必需的。编码的蛋白质以细胞周期依赖性方式被差异磷酸化。此外，它通常存在于细胞核中，但有丝分裂期间除外，此时它会释放到细胞质中。这种蛋白质是 WD-repeat HIR1 家族的成员，也可能参与 DNA 修复。[RefSeq 提供，2008 年 7 月]

Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]

CHAF1B 基因产物(1)

mRNA Protein Name
NM_005441.3 NP_005432.1 chromatin assembly factor 1 subunit B

CHAF1B 蛋白结构

WD40

WD40: WD domain, G-beta repeat (14 - 45)

WD40

WD40: WD domain, G-beta repeat (61 - 94)

WD40

WD40: WD domain, G-beta repeat (119 - 157)

WD40

WD40: WD domain, G-beta repeat (162 - 199)

WD40

WD40: WD domain, G-beta repeat (343 - 370)

CAF-1_p60_C

CAF-1_p60_C: Chromatin assembly factor complex 1 subunit p60, C-terminal (381 - 557)

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  • 559 a.a.
蛋白主名 其他名称

chromatin assembly factor 1 subunit B

CAF-1 subunit B

关联疾病

疾病名称 别名
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Luminal Breast Carcinoma A

Breast Tumor Luminal

Luminal A Breast Carcinoma

Luminal Breast Cancer
Myeloid Leukemia Associated With Down Syndrome
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02595 CHAF1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CHAF1B MGD MGI:1314881
Macaca mulatta CHAF1B VGNC VGNC:80859
Canis familiaris CHAF1B VGNC VGNC:39190
Bos taurus CHAF1B VGNC VGNC:27267
Rattus norvegicus CHAF1B RGD RGD:1307634
Felis catus CHAF1B VGNC VGNC:60836
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