2. Gene
  3. KDM5D - lysine demethylase 5D Gene

KDM5D - lysine demethylase 5D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：赖氨酸脱甲基酶 5D

种属: Homo sapiens

同用名: HY; HYA; SMCY; JARID1D

基因 ID: 8284 | 基因类型: protein coding

关于 KDM5D

Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38): Y:19,703,865-19,744,726 (from NCBI)

This gene has 10 transcripts (splice variants), 110 orthologues, 10 paralogues and is associated with 1 phenotype. Broad expression in small intestine (RPKM 5.6), prostate (RPKM 3.5) and 20 other tissues.

功能概要

该基因编码一种含有锌指结构域的蛋白质。源自该蛋白质的短肽是次要组织相容性抗原，可导致女性受体对男性供体细胞的移植物排斥。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 4 月]

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM5D 基因产物(3)

mRNA Protein Name
NM_001146705.2 NP_001140177.1 lysine-specific demethylase 5D isoform 1
NM_001146706.2 NP_001140178.1 lysine-specific demethylase 5D isoform 3
NM_004653.5 NP_004644.2 lysine-specific demethylase 5D isoform 2

KDM5D 蛋白结构

JmjN

JmjN: jmjN domain (15 - 48)

ARID

ARID: ARID/BRIGHT DNA binding domain (77 - 165)

PHD

PHD: PHD-finger (316 - 362)

JmjC

JmjC: JmjC domain, hydroxylase (491 - 607)

zf-C5HC2

zf-C5HC2: C5HC2 zinc finger (697 - 750)

PLU-1

PLU-1: PLU-1-like protein (761 - 1087)

PHD

PHD: PHD-finger (1174 - 1236)

  • 0
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  • 1539 a.a.
蛋白主名 其他名称

lysine-specific demethylase 5D

H-Y

KDM5D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KDM5D Q9BY66 AR Homo sapiens P10275
Anti Bait CoIP
27185910
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure, Y-Linked, 2

SPGFY2

Spermatogenic Failure, Nonobstructive, Y-Linked

Y-Linked Spermatogenic Failure 2

Azoospermia, Nonobstructive, Y-Linked

Oligozoospermia, Nonobstructive, Y-Linked

Oligospermia, Nonobstructive, Y-Linked

Spermatogenic Arrest, Y-Linked

Nonobstructive Y-Linked Spermatogenic Failure

Spermatogenic Failure Y-Linked 2

Azoospermia Non-Obstructive Y-Linked

Non-Obstructive Azoospermia And Infertility

Oligospermia Non-Obstructive Y-Linked

Oligozoospermia Non-Obstructive Y-Linked

Spermatogenic Arrest Y-Linked

Spermatogenic Failure Nonobstructive Y-Linked
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-102047B KDOAM-25 citrate Inhibitor 98.11% 否
HY-102047 KDOAM-25 Inhibitor / 否
HY-102047A KDOAM-25 trihydrochloride Inhibitor / 否
HY-RS07221 KDM5D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KDM5D MGD MGI:99780
Macaca mulatta KDM5D VGNC VGNC:101430
Rattus norvegicus KDM5D RGD RGD:2314436
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