FZD1 - frizzled class receptor 1 Gene

中文名称：卷曲类受体 1

种属: Homo sapiens

基因 ID: 8321 | 基因类型: protein coding

关于 FZD1

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:91,264,433-91,271,326 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 15 paralogues.

功能概要

“frizzled”基因家族的成员编码 7 个跨膜结构域蛋白，这些蛋白是 Wnt 信号蛋白的受体。 FZD1 蛋白包含一个信号肽、一个位于 N 末端胞外区的富含半胱氨酸的结构域、7 个跨膜结构域和一个 C 末端 PDZ 结构域结合基序。 FZD1 转录物在各种组织中表达。[RefSeq 提供，2008 年 7 月]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

FZD1 基因产物(1)

mRNA	Protein	Name
NM_003505.2	NP_003496.1	frizzled-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	19388021	GOA
enables Wnt receptor activity	IDA IDA: 通过直接分析推断	10557084	GOA
enables Wnt-protein binding	IPI IPI: 通过物理相互作用推断	10557084	GOA
enables frizzled binding	IPI IPI: 通过物理相互作用推断	19188438	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19277043	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	14739301	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autocrine signaling	IDA IDA: 通过直接分析推断	10557084	GOA
involved in canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	10557084	GOA
involved in canonical Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	11433302	GOA
involved in canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	20039315	GOA
involved in cell-cell signaling	IDA IDA: 通过直接分析推断	10557084	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	10557084	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18929644	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: 通过突变表型推断	20039315	GOA
involved in regulation of mesenchymal stem cell differentiation	IMP IMP: 通过突变表型推断	20039315	GOA
involved in response to xenobiotic stimulus	IMP IMP: 通过突变表型推断	19421142	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	19643732	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FZD1 蛋白结构

Frizzled

0
100
200
300
400
500
600
647 a.a.

蛋白主名

其他名称

frizzled-1

Wnt receptor

关联疾病

疾病名称

别名

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Fallopian Tube Serous Adenocarcinoma

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P9974	Vantictumab	Inhibitor	99.40%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05176	FZD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FZD1	MGD	MGI:1196625
Felis catus	FZD1	VGNC	VGNC:62402
Rattus norvegicus	FZD1	RGD	RGD:61916
Canis familiaris	FZD1	VGNC	VGNC:41028
Bos taurus	FZD1	VGNC	VGNC:29165
Others	FZD1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4