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  2. H3C6 - H3 clustered histone 6 Gene

H3C6 - H3 clustered histone 6 Gene

中文名称:H3 成簇组蛋白 6

种属: Homo sapiens

同用名: H3.1; H3/d; H3C1; H3C2; H3C3; H3C4; H3C7; H3C8; H3FD; H3C10; H3C11; H3C12; HIST1H3E

基因 ID: 8353 | 基因类型: protein coding

关于 H3C6

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,224,178-26,227,473 (from NCBI)

This gene has 2 transcripts (splice variants), 72 orthologues and 20 paralogues.

功能概要

组蛋白是基本的核蛋白,负责真核生物染色体纤维的核小体结构。四个核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一个的两个分子形成一个八聚体,大约 146 bp 的 DNA 被包裹在称为核小体的重复单元中。接头组蛋白 H1 与核小体之间的接头 DNA 相互作用,并在将染色质压缩成更高级结构中发挥作用。该基因是无内含子的,编码复制依赖组蛋白,该组蛋白是组蛋白 H3 家族的成员。该基因的转录本缺少 polyA 尾巴,而是包含一个回文终止元件。该基因存在于 6 号染色体上的大型组蛋白基因簇中。[RefSeq 提供,2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H3C6 基因产物(2)

mRNA Protein Name
NM_001381999.1 NP_001368928.1 histone H3.1
NM_003532.3 NP_003523.1 histone H3.1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IDA
IDA: 通过直接分析推断
30867594 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10949293 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epigenetic regulation of gene expression IDA
IDA: 通过直接分析推断
16267050 GOA
acts upstream of positive effect gene expression IDA
IDA: 通过直接分析推断
30867594 GOA
involved in nucleosome assembly IDA
IDA: 通过直接分析推断
14718166 GOA
involved in nucleosome assembly IMP
IMP: 通过突变表型推断
25615412 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of nucleosome IDA
IDA: 通过直接分析推断
14718166 GOA
part of nucleosome IPI
IPI: 通过物理相互作用推断
21812398 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21636898 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
14718166 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

H3C6 蛋白结构

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
蛋白主名 其他名称

histone H3.1

H3 histone family, member D

重组 H3C6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72332 Histone H3 Protein, Human P68431 (A2-A136) ≥95%
HY-P72335 Histone H3 Protein, Human (98a.a, His) P68431 (P39-A136) ≥95%
HY-P72798 Histone H3 Protein, Human (His) P68431 (A2-A136) ≥95%

关联疾病

疾病名称 别名
Histone Mutated Tumor

Histone Mutated Tumour

Brain Stem Cancer

Brain Stem Neoplasms

Malignant Neoplasm Of Brain Stem

Malignant Neoplasm Of Brainstem

Neoplasm Of Adult Brain Stem

Neoplasm Of Brain Stem

Primary Brain Stem Neoplasm

Primary Brain Stem Tumor

Brain Stem Neoplasm

Brain Stem--Cancer

Brain Stem Neoplasms, Primary

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma

Dipg

Infiltrative Brainstem Glioma

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Adult Brainstem Astrocytoma

Adult Brain Stem Astrocytoma

Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome

Posterior Fossa Ependymoma
Clear Cell Chondrosarcoma

Chondrosarcoma, Clear Cell

Brain Stem Glioma

Brainstem Glioma

Brainstem Neuroglial Tumor

Glioma Of Brainstem

Spinal Cord Astrocytoma

Astrocytoma Of Spinal Cord

Spinal Astrocytoma

Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma

Spinal Cord Glioma

Glial Tumor Of Spinal Cord

Glial Neoplasm Spinal Cord

Glioma Of Spinal Cord

Anaplastic Pleomorphic Xanthoastrocytoma
Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

CMTX3

Charcot-Marie-Tooth Disease X-Linked Recessive 3

Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3

Cmt3x

X-Linked Charcot-Marie-Tooth Disease Type 3

Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3

Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive

Hyperinsulinemic Hypoglycemia, Familial, 3

HHF3

Hyperinsulinism Due To Glucokinase Deficiency

Familial Hyperinsulinemic Hypoglycemia 3

Hyperinsulinemic Hypoglycemia Due To Glucokinase Deficiency

Hyperinsulinemic Hypoglycemia Familial 3

Congenital Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Hypoglycemia, Hyperinsulinemic, Familial, Type 3

High Grade Ependymoma

Ependymal Neoplasm

Ependymal Tumors

Malignant Ependymoma

Ependymal Tumor

Anaplastic Ependymoma

Experimental Organism Malignant Ependymoma

Ependymoma Of Brain

Astrocytoma, Idh-Mutant, Grade 4

Idh-Mutant Glioblastoma

Pleomorphic Xanthoastrocytoma

Pxa

Pleomorphic Xantho-Astrocytoma

Idh-Wildtype Glioblastoma
Juvenile Pilocytic Astrocytoma
Diffuse Astrocytoma

Diffuse Astrocytoma, Low Grade

Who Grade Ii Astrocytoma

Fibrillary Astrocytoma

Gemistocytic Astrocytoma

Low-Grade Diffuse Astrocytoma

Protoplasmic Astrocytoma

Spinal Cancer

Spinal Cord Neoplasm

Spinal Cord Neoplasms

Spinal Neoplasms

Intraspinal Tumor

Malignant Tumor Of The Spinal Cord

Spinal Cord Cancer

Spinal Neoplasm

Tumor Of The Spinal Cord

Tumors Spinal Cord

Intraspinal Neoplasm

Spinal Cord--Cancer

Pilomyxoid Astrocytoma
Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms

Cerebral Ventricle Neoplasm

Intraventricular Tumor Of Brain

Supratentorial Ependymoma
Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma

Intracranial Structure Hemangioma

Angioma Of Intracranial Structure

Hemangioma Of Intracranial Structure

Hemangioma Of Intracranial Structures

Low Grade Glioma

Benign Glioma

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Supratentorial Cancer

Supratentorial Neoplasms

Brain Neoplasm, Supratentorial

Malignant Supratentorial Tumor

Cancer, Supratentorial

Cerebrum Cancer

Cerebral Cancer

Neoplasm Of Cerebrum

Tumor Of Cerebrum

Malignant Neoplasm Of Cerebrum

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma

Grade I Astrocytic Tumor

Piloid Astrocytoma

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome

Rtps

Atypical Teratoid/Rhabdoid Tumor

Rhabdoid Predisposition Syndrome

Familial Posterior Fossa Brain Tumor Of Infancy

Familial Rhabdoid Tumor

At/Rt

Atypical Teratoid Rhabdoid Tumour

Atypical Teratoid/Rhabdoid Tumour

Rhabdoid Tumor Of The Cns

Rhabdoid Tumour Of The Cns

Familial Posterior Fossa Brain Tumor Syndrome

Hereditary Swi/Snf Deficiency Syndrome

Atrt

Infratentorial Cancer

Infratentorial Neoplasms

Brain Neoplasm, Infratentorial

Malignant Infratentorial Tumors

Spinal Cord Disease

Spinal Cord Diseases

Myelopathy

Bone Marrow Diseases

Anaplastic Oligodendroglioma
Anaplastic Astrocytoma

Grade Iii Astrocytoma

Astrocytoma, Anaplastic

Grade Iii Astrocytic Tumor

Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome

Giant Cell Glioblastoma

Monstrocellular Sarcoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus H3C6 MGD MGI:2448349
Rattus norvegicus H3C6 RGD RGD:1311554