H4C2 - H4 clustered histone 2 Gene

中文名称：H4 成簇组蛋白 2

种属: Homo sapiens

同用名: H4/I; H4C1; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FI; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4B

基因 ID: 8366 | 基因类型: protein coding

关于 H4C2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,026,896-26,027,283 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues, 14 paralogues and is associated with 1 phenotype.

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。四个核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一个的两个分子形成一个八聚体，大约 146 bp 的 DNA 被包裹在称为核小体的重复单元中。接头组蛋白 H1 与核小体之间的接头 DNA 相互作用，并在将染色质压缩成更高级结构中发挥作用。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H4 家族的成员。该基因的转录本缺少 polyA 尾巴，而是包含一个回文终止元件。该基因存在于 6 号染色体上的大型组蛋白基因簇中。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H4C2 基因产物(1)

mRNA	Protein	Name
NM_003544.3	NP_003535.1	histone H4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9540062	GOA
enables structural constituent of chromatin	IDA IDA: 通过直接分析推断	14718166	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of megakaryocyte differentiation	IDA IDA: 通过直接分析推断	18474616	GOA
involved in nucleosome assembly	IDA IDA: 通过直接分析推断	14718166	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CENP-A containing nucleosome	IPI IPI: 通过物理相互作用推断	21743476	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	14718166	GOA
part of nucleosome	IPI IPI: 通过物理相互作用推断	20498094	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14585971	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	14718166	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

H4C2 蛋白结构

Histone

0
103 a.a.

蛋白主名

其他名称

histone H4

H4 histone family, member I

重组 H4C2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72336	Histone H4 Protein, Human/Xenopus laevis	P62805 (S2-G103)	≥95%

关联疾病

疾病名称

别名

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Basilicata-Akhtar Syndrome

Mrxs36	MRXSBA
Mental Retardation, X-Linked, Syndromic, Basilicata-Akhtar Type	Mental Retardation, X-Linked, Syndromic 36
X-Linked Syndromic Mental Retardation 36	X-Linked Syndromic Mental Retardation Basilicata-Akhtar Type

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability
Rts

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05975	H4C2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	H4C2	MGD	MGI:2448443
Rattus norvegicus	H4C2	RGD	RGD:1307448

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

H4C2 - H4 clustered histone 2 Gene

关于 H4C2

功能概要

H4C2 基因产物(1)

H4C2 蛋白结构

重组 H4C2 蛋白

关联疾病

直系同源

热门区域

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H4C2 - H4 clustered histone 2 Gene

关于 H4C2

功能概要

H4C2 基因产物(1)

H4C2 蛋白结构

重组 H4C2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z