JAM3 - junctional adhesion molecule 3 Gene

中文名称：连接粘附分子 3

种属: Homo sapiens

同用名: JAMC; JAM-2; JAM-3; JAM-C

基因 ID: 83700 | 基因类型: protein coding

关于 JAM3

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,069,072-134,152,001 (from NCBI)

This gene has 8 transcripts (splice variants), 276 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 57.0), testis (RPKM 33.0) and 22 other tissues.

功能概要

紧密连接代表上皮或内皮细胞片中细胞间粘附的一种模式，在细胞周围形成连续密封，并作为物理屏障防止溶质和水自由通过细胞旁空间。由该免疫球蛋白超家族基因成员编码的蛋白质位于高内皮细胞之间的紧密连接处。与该家族中的其他蛋白质不同，该蛋白质无法粘附在白细胞细胞系上，只能形成弱的同型相互作用。编码的蛋白质是连接粘附分子蛋白质家族的成员，并充当该家族另一个成员的受体。该基因内含子的突变与脑出血性破坏、室管膜下钙化和先天性白内障有关。可变剪接导致多个转录变体。[RefSeq 提供，2011 年 4 月]

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike Other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

JAM3 基因产物(2)

mRNA	Protein	Name
NM_001205329.2	NP_001192258.1	junctional adhesion molecule C isoform 2 precursor
NM_032801.5	NP_116190.3	junctional adhesion molecule C isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cell-cell adhesion mediator activity	IDA IDA: 通过直接分析推断	11823489	GOA
enables integrin binding	IPI IPI: 通过物理相互作用推断	12208882	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11590146	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adherens junction assembly	IMP IMP: 通过突变表型推断	19060272	GOA
involved in angiogenesis	IDA IDA: 通过直接分析推断	20592283	GOA
involved in apical protein localization	IMP IMP: 通过突变表型推断	19060272	GOA
involved in cell-cell adhesion	IDA IDA: 通过直接分析推断	11823489	GOA
involved in cell-cell adhesion	IMP IMP: 通过突变表型推断	24357068	GOA
involved in granulocyte migration	IMP IMP: 通过突变表型推断	19060272	GOA
involved in hematopoietic stem cell migration to bone marrow	IMP IMP: 通过突变表型推断	24357068	GOA
involved in heterotypic cell-cell adhesion	IDA IDA: 通过直接分析推断	12208882	GOA
involved in negative regulation of cell adhesion mediated by integrin	IMP IMP: 通过突变表型推断	19461049	GOA
involved in negative regulation of integrin activation	IMP IMP: 通过突变表型推断	19461049	GOA
acts upstream of or within positive regulation of membrane permeability	IMP IMP: 通过突变表型推断	31926946	GOA
acts upstream of or within positive regulation of monocyte extravasation	IMP IMP: 通过突变表型推断	31926946	GOA
involved in protein localization to cell junction	IMP IMP: 通过突变表型推断	19060272	GOA
involved in protein localization to cell surface	IMP IMP: 通过突变表型推断	19060272	GOA
involved in regulation of neutrophil chemotaxis	IDA IDA: 通过直接分析推断	15194813	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with bicellular tight junction	IDA IDA: 通过直接分析推断	28196865	GOA
located in cell-cell contact zone	IDA IDA: 通过直接分析推断	15994945	GOA
located in cell-cell junction	IMP IMP: 通过突变表型推断	19461049	GOA
located in desmosome	IDA IDA: 通过直接分析推断	15194813	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	20592283	GOA
part of filamentous actin	IDA IDA: 通过直接分析推断	19060272	GOA
located in microvillus	IDA IDA: 通过直接分析推断	19060272	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11590146	GOA
part of protein complex involved in cell adhesion	IDA IDA: 通过直接分析推断	11590146	GOA
located in tight junction	IDA IDA: 通过直接分析推断	19060272	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JAM3 蛋白结构

V-set

Ig_2

0
100
200
310 a.a.

蛋白主名

其他名称

junctional adhesion molecule C

JAM3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	JAM3	Q9BX67	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	JAM3	Q9BX67	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	JAM3	Q9BX67	JAM2	Homo sapiens	P57087	Protein Array	21982860

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 JAM3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73850	JAM-C/CD323 Protein, Human (HEK293, Fc)	Q9BX67 (V32-N241)	≥95%
HY-P73851	JAM-C/CD323 Protein, Human (HEK293)	Q9BX67 (V32-N241)	≥95%

关联疾病

疾病名称

别名

Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts

Porencephaly-Microcephaly-Bilateral Congenital Cataract Syndrome	HDBSCC
Hemorrhagic Destruction Of The Brain With Subependymal Calcification And Cataracts	Hemorrhagic Destruction Of The Brain, Subependymal Calcification, Cataracts

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Pseudo-Torch Syndrome 1

Pseudo-Torch Syndrome	Band-Like Calcification With Simplified Gyration And Polymicrogyria
Blcpmg	PTORCH1
Baraitser-Brett-Piesowicz Syndrome	Baraitser-Reardon Syndrome
Bilateral Band-Like Calcification With Polymicrogyria	Blc-Pmg
Microcephaly-Intracranial Calcification-Intellectual Disability Syndrome	Congenital Intrauterine Infection-Like Syndrome
Baraitser Brett Piesowicz Syndrome	Microcephaly - Intracranial Calcification - Intellectual Disability

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07028	JAM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	JAM3	RGD	RGD:1303248
Mus musculus	JAM3	MGD	MGI:1933825
Macaca mulatta	JAM3	VGNC	VGNC:73836
Canis familiaris	JAM3	VGNC	VGNC:53419
Bos taurus	JAM3	VGNC	VGNC:50018
Felis catus	JAM3	VGNC	VGNC:63002
Others	JAM3	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

JAM3 - junctional adhesion molecule 3 Gene

关于 JAM3

功能概要

JAM3 基因产物(2)

JAM3 蛋白结构

JAM3 蛋白互作信息

重组 JAM3 蛋白

关联疾病

直系同源

热门区域

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JAM3 - junctional adhesion molecule 3 Gene

关于 JAM3

功能概要

JAM3 基因产物(2)

JAM3 蛋白结构

JAM3 蛋白互作信息

重组 JAM3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z