2. Gene
  3. SLC25A18 - solute carrier family 25 member 18 Gene

SLC25A18 - solute carrier family 25 member 18 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 25 成员 18

种属: Homo sapiens

同用名: GC2

基因 ID: 83733 | 基因类型: protein coding

关于 SLC25A18

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,563,498-17,590,995 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 49 paralogues. Biased expression in brain (RPKM 15.7), liver (RPKM 8.1) and 2 other tissues.

功能概要

预测启用 L-天冬氨酸跨膜转运蛋白活性和 L-谷氨酸跨膜转运蛋白活性。预计参与 L-谷氨酸跨膜转运；天冬氨酸跨膜转运；和苹果酸天冬氨酸穿梭。预测位于线粒体内膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC25A18 基因产物(2)

mRNA Protein Name
NM_001303484.2 NP_001290413.1 mitochondrial glutamate carrier 2
NM_031481.3 NP_113669.1 mitochondrial glutamate carrier 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amino acid:proton symporter activity IDA
IDA: 通过直接分析推断
11897791 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-glutamate transmembrane transport IDA
IDA: 通过直接分析推断
11897791 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A18 蛋白结构

Mito_carr

Mito_carr: Mitochondrial carrier protein (5 - 95)

Mito_carr

Mito_carr: Mitochondrial carrier protein (105 - 209)

Mito_carr

Mito_carr: Mitochondrial carrier protein (218 - 302)

  • 0
  • 100
  • 200
  • 315 a.a.
蛋白主名 其他名称

mitochondrial glutamate carrier 2

glutamate/H(+) symporter 2

SLC25A18 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC25A18 Q9H1K4 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
种属内
SLC25A18 Q9H1K4 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
种属内
SLC25A18 Q9H1K4 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
种属内
SLC25A18 Q9H1K4 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
种属内
SLC25A18 Q9H1K4 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
种属内
SLC25A18 Q9H1K4 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
种属内
SLC25A18 Q9H1K4 GOPC Homo sapiens Q9HD26
Y2H Prey Pooling
25416956
种属内
SLC25A18 Q9H1K4 GOPC Homo sapiens Q9HD26
Y2H Array
25416956
种属内
SLC25A18 Q9H1K4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
SLC25A18 Q9H1K4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leber Congenital Amaurosis 12

LCA12

Leber Congenital Amaurosis, Type 12
Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral

Agc1 Deficiency

Epileptic Encephalopathy, Early Infantile, 39

DEE39

Eiee39

Aspartate-Glutamate Carrier 1 Deficiency

Epileptic Encephalopathy With Global Cerebral Demyelination

Developmental And Epileptic Encephalopathy, 39

Early Infantile Epileptic Encephalopathy 39

Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency

Global Cerebral Hypomyelination

Hereditary Central Nervous System Demyelinating Diseases
Phencyclidine Abuse

Pcp Abuse
Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13098 SLC25A18 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC25A18 MGD MGI:1919053
Rattus norvegicus SLC25A18 RGD RGD:1590470
Canis familiaris SLC25A18 VGNC VGNC:46297
Felis catus SLC25A18 VGNC VGNC:65260
Macaca mulatta SLC25A18 VGNC VGNC:77434
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