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  2. TAS1R3 - taste 1 receptor member 3 Gene

TAS1R3 - taste 1 receptor member 3 Gene

中文名称:味觉 1 受体成员 3

种属: Homo sapiens

同用名: T1R3

基因 ID: 83756 | 基因类型: protein coding

关于 TAS1R3

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,331,280-1,335,314 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues.

功能概要

该基因编码的蛋白质是一种参与味觉反应的 G 蛋白偶联受体。编码的蛋白质可以与 TAS1R1 形成异二聚体受体以引发鲜味反应,也可以与 TAS1R2 结合形成甜味反应受体。[RefSeq 提供,2015 年 11 月]

The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

TAS1R3 基因产物(1)

mRNA Protein Name
NM_152228.3 NP_689414.2 taste receptor type 1 member 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to sweet taste receptor activity IDA
IDA: 通过直接分析推断
16720576 GOA
contributes to taste receptor activity IDA
IDA: 通过直接分析推断
16720576 GOA
enables taste receptor activity IPI
IPI: 通过物理相互作用推断
11917125 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in detection of chemical stimulus involved in sensory perception of sweet taste IDA
IDA: 通过直接分析推断
16720576 GOA
involved in sensory perception of sweet taste IDA
IDA: 通过直接分析推断
11917125 GOA
involved in sensory perception of umami taste IDA
IDA: 通过直接分析推断
11917125 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of sweet taste receptor complex IDA
IDA: 通过直接分析推断
16720576 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAS1R3 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (72 - 462)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (495 - 547)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (581 - 817)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 852 a.a.
蛋白主名 其他名称

taste receptor type 1 member 3

sweet taste receptor T1R3

关联疾病

疾病名称 别名
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis

Renal Pelvis Urothelial Carcinoma

Transitional Cell Carcinoma Of Renal Pelvis

Glucocorticoid Deficiency 1

Acth Resistance

Glucocorticoid Deficiency, Due To Acth Unresponsiveness

GCCD1

Familial Glucocorticoid Deficiency 1

Fgd1

Adrenal Unresponsiveness To Acth

Hereditary Unresponsiveness To Adrenocorticotropic Hormone

Isolated Glucocorticoid Deficiency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TAS1R3 VGNC VGNC:47113
Macaca mulatta TAS1R3 VGNC VGNC:106513
Bos taurus TAS1R3 VGNC VGNC:106965
Rattus norvegicus TAS1R3 RGD RGD:620539
Felis catus TAS1R3 VGNC VGNC:80375
Mus musculus TAS1R3 MGD MGI:1933547