2. Gene
  3. NME5 - NME/NM23 family member 5 Gene

NME5 - NME/NM23 family member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NME/NM23 家族成员 5

种属: Homo sapiens

同用名: CILD48; NM23H5; RSPH23; NM23-H5

基因 ID: 8382 | 基因类型: protein coding

关于 NME5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,115,175-138,139,428 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 8 paralogues. Biased expression in testis (RPKM 15.2), kidney (RPKM 4.4) and 8 other tissues.

功能概要

预测可启用核苷二磷酸激酶活性。预计参与氧化应激诱导的内在凋亡信号通路和精子细胞发育的负调控。预计在纤毛组装体的上游或内部起作用；上皮纤毛运动参与细胞外液运动；和心室系统发育。预测位于纤毛中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or within cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and ventricular system development. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]

NME5 基因产物(1)

mRNA Protein Name
NM_003551.3 NP_003542.1 nucleoside diphosphate kinase homolog 5
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' exonuclease activity IDA
IDA: 通过直接分析推断
16313181 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in spermatid development IMP
IMP: 通过突变表型推断
32185794 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NME5 蛋白结构

NDK

NDK: Nucleoside diphosphate kinase (13 - 145)

Dpy-30

Dpy-30: Dpy-30 motif (157 - 197)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

nucleoside diphosphate kinase homolog 5

IPIA-beta

NME5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NME5 P56597 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
种属内
NME5 P56597 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
种属内
NME5 P56597 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Pooling
16189514
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
25416956
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
25416956
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
32296183
种属内
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Array
25416956
种属内
NME5 P56597 DYDC2 Homo sapiens Q96IM9
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 48, Without Situs Inversus

CILD48
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09376 NME5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NME5 MGD MGI:1922783
Macaca mulatta NME5 VGNC VGNC:84453
Felis catus NME5 VGNC VGNC:68504
Rattus norvegicus NME5 RGD RGD:1583004
Bos taurus NME5 VGNC VGNC:32127
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z