2. Gene
  3. USP26 - ubiquitin specific peptidase 26 Gene

USP26 - ubiquitin specific peptidase 26 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 26

种属: Homo sapiens

基因 ID: 83844 | 基因类型: protein coding

关于 USP26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:133,023,168-133,097,109 (from NCBI)

This gene has 3 transcripts (splice variants), 15 orthologues and 71 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码泛素特异性加工 (UBP) 蛋白酶家族的成员，是一种具有 His 和 Cys 结构域的去泛素化酶 (DUB) 。它在睾丸组织中特异性表达。该基因的突变与仅支持细胞综合征和男性不育症有关。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating Enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

USP26 基因产物(1)

mRNA Protein Name
NM_031907.3 NP_114113.1 ubiquitin carboxyl-terminal hydrolase 26
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K48-linked deubiquitinase activity IDA
IDA: 通过直接分析推断
28839133 GOA
enables deubiquitinase activity IDA
IDA: 通过直接分析推断
20501646 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20501646 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
28839133 GOA
involved in regulation of androgen receptor signaling pathway IMP
IMP: 通过突变表型推断
20501646 GOA
involved in spermatogenesis IMP
IMP: 通过突变表型推断
34202084 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
20501646 GOA
located in sperm flagellum IMP
IMP: 通过突变表型推断
34202084 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP26 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (295 - 883)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 913 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 26

deubiquitinating enzyme 26

关联疾病

疾病名称 别名
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Infertility
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome

Germinal Cell Aplasia

Del Castillo Syndrome

SPGFX1

X-Linked Spermatogenic Failure 1

Congenital Absence Of Germinal Epithelium Of Testes
Tonne-Kalscheuer Syndrome

TOKAS

Mrx61

Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia

Mental Retardation, X-Linked 61

X-Linked Mental Retardation 61
Benign Pleural Mesothelioma

Mesothelioma Of Pleura

Benign Neoplasm Of Mesothelial Tissue Of Pleura

Pleural Malignant Mesothelioma
Acquired Hyperkeratosis

Acquired Keratoderma

Keratoderma - Acquired

Keratoderma, Acquired

Keratosis Blennorrhagica
Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence
Oligospermia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15536 USP26 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus USP26 RGD RGD:1563443
Bos taurus USP26 VGNC VGNC:36719
Canis familiaris USP26 VGNC VGNC:48185
Mus musculus USP26 MGD MGI:1933247
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