CDCA7 - cell division cycle associated 7 Gene

中文名称：细胞分裂周期相关 7

种属: Homo sapiens

同用名: ICF3; JPO1

基因 ID: 83879 | 基因类型: protein coding

关于 CDCA7

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:173,354,872-173,368,997 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 15.2), duodenum (RPKM 15.1) and 14 other tissues.

功能概要

该基因被鉴定为 c-Myc 反应基因，并且表现为直接的 c-Myc 靶基因。发现该基因的过表达可增强类淋巴母细胞的转化，并且它补充了转化缺陷型 Myc Box II 突变体，表明其参与了 c-Myc 介导的细胞转化。已经报道了编码不同亚型的两种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

CDCA7 基因产物(2)

mRNA	Protein	Name
NM_031942.5	NP_114148.3	cell division cycle-associated protein 7 isoform 1
NM_145810.3	NP_665809.1	cell division cycle-associated protein 7 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11598121	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	11598121	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDCA7 蛋白结构

zf-4CXXC_R1

0
100
200
300
371 a.a.

蛋白主名

其他名称

cell division cycle-associated protein 7

c-Myc target JPO1

CDCA7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDCA7	Q9BWT1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	CDCA7	Q9BWT1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	CDCA7	Q9BWT1	WFS1	Homo sapiens	O76024	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3

ICF3	Icf Syndrome 3
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome, Type 3

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1

Immunodeficiency Syndrome, Variable	ICF1
Ciid	Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16
Centromeric Instability, Immunodeficiency Syndrome	Icf Syndrome 1
Centromeric Instability Immunodeficiency Syndrome	Icf Syndrome
Variable Immune Deficiency With Centromeric Instability Of Chromosomes 1 9 And 16	Variable Immunodeficiency Syndrome
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome, Type 1	Common Variable Immunodeficiency
Chromosomal Instability

Hepatic Venoocclusive Disease With Immunodeficiency

VODI	Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatic Veno-Occlusive Disease With Immunodeficiency	Familial Veno-Occlusive Disease With Immunodeficiency
Veno-Occlusive Disease And Immunodeficiency Syndrome	Vodi Syndrome
Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02315	CDCA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS02316	CDCA7L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CDCA7	RGD	RGD:1309363
Macaca mulatta	CDCA7	VGNC	VGNC:70713
Bos taurus	CDCA7	VGNC	VGNC:27086
Mus musculus	CDCA7	MGD	MGI:1914203
Felis catus	CDCA7	VGNC	VGNC:60668

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CDCA7 - cell division cycle associated 7 Gene

关于 CDCA7

功能概要

CDCA7 基因产物(2)

CDCA7 蛋白结构

CDCA7 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CDCA7 - cell division cycle associated 7 Gene

关于 CDCA7

功能概要

CDCA7 基因产物(2)

CDCA7 蛋白结构

CDCA7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z