SLC25A11 - solute carrier family 25 member 11 Gene

中文名称：溶质载体家族 25 成员 11

种属: Homo sapiens

同用名: OGC; PGL6; SLC20A4

基因 ID: 8402 | 基因类型: protein coding

关于 SLC25A11

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,937,130-4,940,046 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues, 49 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 61.1), kidney (RPKM 32.4) and 24 other tissues.

功能概要

氧戊二酸/苹果酸载体将 2-氧戊二酸转运穿过线粒体的内膜，与苹果酸或其他二羧酸进行电中性交换 (Iacobazzi 等人总结，1992 [PubMed 1457818]) 。[OMIM 提供，2011 年 1 月]

The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or Other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

SLC25A11 基因产物(3)

mRNA	Protein	Name
NM_001165417.2	NP_001158889.1	mitochondrial 2-oxoglutarate/malate carrier protein isoform 2
NM_001165418.2	NP_001158890.1	mitochondrial 2-oxoglutarate/malate carrier protein isoform 3
NM_003562.5	NP_003553.2	mitochondrial 2-oxoglutarate/malate carrier protein isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A11 蛋白结构

Mito_carr

0
100
200
314 a.a.

蛋白主名

其他名称

mitochondrial 2-oxoglutarate/malate carrier protein

OGCP

SLC25A11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC25A11	Q02978	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
种属内	SLC25A11	Q02978	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
种属内	SLC25A11	Q02978	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
种属内	SLC25A11	Q02978	AHCYL1	Homo sapiens	O43865	Validated Y2H	32814053
种属内	SLC25A11	Q02978	AHCYL1	Homo sapiens	O43865	Y2H Array	32814053
种属内	SLC25A11	Q02978	AHCYL1	Homo sapiens	O43865	Y2H Pooling	32814053
种属内	SLC25A11	Q02978	DLST	Homo sapiens	P36957	Validated Y2H	32814053
种属内	SLC25A11	Q02978	DLST	Homo sapiens	P36957	Y2H Array	32814053
种属内	SLC25A11	Q02978	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
种属内	SLC25A11	Q02978	SMIM26	Homo sapiens	A0A096LP01	Anti Tag CoIP	37009826
种属内	SLC25A11	Q02978	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
种属内	SLC25A11	Q02978	CDH1	Homo sapiens	P12830	Y2H Array	32814053
种属内	SLC25A11	Q02978	CDH1	Homo sapiens	P12830	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Paragangliomas 6

PGL6

Hereditary Paraganglioma-Pheochromocytoma Syndromes

Hereditary Pheochromocytoma-Paraganglioma	Hereditary Paraganglioma-Pheochromocytoma
Familial Pheochromocytoma-Paraganglioma	Paragangliomas 2
Paragangliomas 3	Paragangliomas 4
Sdhx-Related Paraganglioma-Pheochromocytoma	Familial Paraganglioma Syndrome
Familial Paraganglioma-Pheochromocytoma Syndromes	Fpgl
Fpgl/Pheo	Paragangliomas 1
Paraganglioma

Breast Leiomyosarcoma

Leiomyosarcoma Of The Breast

Oculogyric Crisis

Aromatic L-Amino Acid Decarboxylase Deficiency

Aadc Deficiency	Dopa Decarboxylase Deficiency
Ddc Deficiency	Aromatic Amino Acid Decarboxylase Deficiency
Deficiency Of Aromatic-L-Amino-Acid Decarboxylase	AADCD
Aromatic-L-Amino-Acid Decarboxylase Deficiency	Aromatic L-Amino-Acid Decarboxylase Deficiency

Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral	Agc1 Deficiency
Epileptic Encephalopathy, Early Infantile, 39	DEE39
Eiee39	Aspartate-Glutamate Carrier 1 Deficiency
Epileptic Encephalopathy With Global Cerebral Demyelination	Developmental And Epileptic Encephalopathy, 39
Early Infantile Epileptic Encephalopathy 39	Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency
Global Cerebral Hypomyelination	Hereditary Central Nervous System Demyelinating Diseases

Lung Giant Cell Carcinoma

Carcinoma, Giant Cell	Giant Cell Carcinoma
Giant Cell Lung Carcinoma	Carcinoma Giant Cell
Giant Cell Carcinoma Of Lung

Persistent Generalized Lymphadenopathy

Pgl	Persistant Generalized Lymphadenopathy

Postencephalitic Parkinson Disease

Postencephalitic Parkinsonism

Parkinson Disease, Postencephalitic

Pancreatic Mucinous Cystadenoma

Pancreatic Mucinous Cystic Neoplasm

Pancreatic Mucinous-Cystic Neoplasm

Citrullinemia, Type Ii, Adult-Onset

Citrin Deficiency	CTLN2
Citrullinemia Type Ii	Adult-Onset Citrullinemia Type 2
Adult-Onset Type Ii Citrullinemia	Citrullinemia, Adult-Onset Type Ii
Adult-Onset Citrin Deficiency	Adult-Onset Citrullinemia Type Ii
Citrullinemia Type 2	Citrullinemia 2
Citrullinemia, Type Ii

Hyperphenylalaninemia, Bh4-Deficient, A

6-Pyruvoyl-Tetrahydropterin Synthase Deficiency	Pts Deficiency
HPABH4A	Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To Pts Deficiency
Ptsd	Bh4-Deficient Hyperphenylalaninemia A
Hyperphenylalaninemia Due To 6-Pyruvoyltetrahydropterin Synthase Deficiency	Tetrahydobioperin-Deficient Hyperphenylalaninemia Due To Pts Deficiency
Hyperphenylalanemia, Bh4-Deficient, A	Hyperphenylalaninemia Due To 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
6-Pyruvoyltetrahydropterin Synthase Deficiency	Hyperphenylalaninemia Tetrahydrobiopterin-Deficient Due To Pts Deficiency
Ptpsd	Hyperphenylalaninemia, Bh4-Deficient, Type A

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13091	SLC25A11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SLC25A11	VGNC	VGNC:46291
Macaca mulatta	SLC25A11	VGNC	VGNC:77429
Mus musculus	SLC25A11	MGD	MGI:1915113
Bos taurus	SLC25A11	VGNC	VGNC:34742
Felis catus	SLC25A11	VGNC	VGNC:65253
Rattus norvegicus	SLC25A11	RGD	RGD:708476

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC25A11 - solute carrier family 25 member 11 Gene

关于 SLC25A11

功能概要

SLC25A11 基因产物(3)

SLC25A11 蛋白结构

SLC25A11 蛋白互作信息

关联疾病

直系同源

热门区域

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SLC25A11 - solute carrier family 25 member 11 Gene

关于 SLC25A11

功能概要

SLC25A11 基因产物(3)

SLC25A11 蛋白结构

SLC25A11 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z