ANTXR1 - ANTXR cell adhesion molecule 1 Gene

中文名称：ANTXR 细胞粘附分子 1

种属: Homo sapiens

同用名: ATR; GAPO; TEM8

基因 ID: 84168 | 基因类型: protein coding

关于 ANTXR1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,013,144-69,249,327 (from NCBI)

This gene has 11 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in gall bladder (RPKM 37.4), ovary (RPKM 30.6) and 21 other tissues.

功能概要

该基因编码 I 型跨膜蛋白，是一种与结直肠癌有关的肿瘤特异性内皮标记物。编码的蛋白质已被证明也是炭疽杆菌毒素的停靠蛋白或受体，炭疽杆菌毒素是炭疽病的病原体。三联炭疽毒素的保护性抗原 (PA) 成分与该受体蛋白的结合介导毒素成分向细胞胞质溶胶的递送。一旦进入细胞，炭疽毒素的另外两种成分水肿因子 (EF) 和致死因子 (LF) 就会破坏正常的细胞过程。已经描述了编码不同蛋白质同种型的三种可变剪接变体。[RefSeq 提供，2008 年 10 月]

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal Cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the Other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

ANTXR1 基因产物(4)

mRNA	Protein	Name
NM_001410840.1	NP_001397769.1	anthrax toxin receptor 1 isoform 4 precursor
NM_018153.3	NP_060623.2	anthrax toxin receptor 1 isoform 3 precursor
NM_032208.3	NP_115584.1	anthrax toxin receptor 1 isoform 1 precursor
NM_053034.2	NP_444262.1	anthrax toxin receptor 1 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin filament binding	IDA IDA: 通过直接分析推断	16762926	GOA
enables collagen binding	IDA IDA: 通过直接分析推断	16762926	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14507921	GOA
enables transmembrane signaling receptor activity	IDA IDA: 通过直接分析推断	16762926	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin cytoskeleton organization	IDA IDA: 通过直接分析推断	16762926	GOA
involved in substrate adhesion-dependent cell spreading	IDA IDA: 通过直接分析推断	16762926	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	21129411	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	21129411	GOA
located in filopodium membrane	IDA IDA: 通过直接分析推断	16762926	GOA
located in lamellipodium membrane	IDA IDA: 通过直接分析推断	16762926	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANTXR1 蛋白结构

VWA

Anth_Ig

Ant_C

0
100
200
300
400
500
564 a.a.

蛋白主名

其他名称

anthrax toxin receptor 1

2310008J16Rik

重组 ANTXR1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7521	TEM8/ANTXR1 Protein, Human	Q9H6X2-4 (E33-K321)	≥95%
HY-P77226	TEM8/ANTXR1 Protein, Human (HEK293, Fc)	Q9H6X2-1 (E33-S321)	≥95%

关联疾病

疾病名称

别名

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Hemangioma, Capillary Infantile

HCI	Capillary Infantile Hemangioma
Hemangioma, Hereditary Capillary	Hemangioma, Capillary Infantile, Susceptibility To
Hemangioma, Capillary Infantile, Somatic	Hemangioma Hereditary Capillary

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Hemangioma

Hemangiomas

Hyaline Fibromatosis Syndrome

Juvenile Hyaline Fibromatosis	Inherited Systemic Hyalinosis
Puretic Syndrome	Infantile Systemic Hyalinosis
HFS	Hyalinosis, Systemic
Systemic Hyalinosis	Molluscum Fibrosum
Murray Syndrome	Murray-Puretic-Drescher Syndrome
Ish	Jhf
Fibromatosis, Juvenile Hyaline	Hyalinosis, Systemic Infantile
Fibromatosis, Hyaline Syndrome	Neurofibromatosis 1

Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax

Inhalation Anthrax

Pulmonary Anthrax	Respiratory Anthrax
Inhalational Anthrax	Wool-Sorters' Disease
Woolsorters' Disease	Inhalation Anthrax Disease
Respiratory Anthrax Disease

Gastrointestinal Anthrax

Oropharyngeal Anthrax

Gingival Hypertrophy

Hypertrophy Of Gingivae

Capillary Hemangioma

Infantile Hemangioma	Strawberry Nevus Of Skin
Cellular Hemangioma Of Infancy	Congenital Vascular Hamartoma
Congenital Vascular Naevus	Juvenile Hemangioma
Strawberry Haemangioma	Strawberry Nevus
Hemangioma Capillary	Hemangioma, Capillary
Hemangioma, Cavernous

Bardet-Biedl Syndrome 2

BBS2	Bardet-Biedl Syndrome
Bardet-Biedl Syndrome, Type 2	Bbs

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Capillary Disease

Disease Of Capillaries

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00755	ANTXR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ANTXR1	VGNC	VGNC:37935
Rattus norvegicus	ANTXR1	RGD	RGD:1307144
Macaca mulatta	ANTXR1	VGNC	VGNC:69873
Felis catus	ANTXR1	VGNC	VGNC:59837
Bos taurus	ANTXR1	VGNC	VGNC:25961
Mus musculus	ANTXR1	MGD	MGI:1916788
Others	ANTXR1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ANTXR1 - ANTXR cell adhesion molecule 1 Gene

关于 ANTXR1

功能概要

ANTXR1 基因产物(4)

ANTXR1 蛋白结构

重组 ANTXR1 蛋白

关联疾病

直系同源

热门区域

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ANTXR1 - ANTXR cell adhesion molecule 1 Gene

关于 ANTXR1

功能概要

ANTXR1 基因产物(4)

ANTXR1 蛋白结构

重组 ANTXR1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z