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  2. MAF1 - MAF1 homolog, negative regulator of RNA polymerase III Gene

MAF1 - MAF1 homolog, negative regulator of RNA polymerase III Gene

中文名称:MAF1 同源物,RNA 聚合酶 III 的负调节因子

种属: Homo sapiens

基因 ID: 84232 | 基因类型: protein coding

关于 MAF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,104,461-144,107,611 (from NCBI)

This gene has 6 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in fat (RPKM 39.1), ovary (RPKM 34.7) and 25 other tissues.

功能概要

该基因编码一种类似于 Maf1 的蛋白质,Maf1 是一种在真核细胞中高度保守的酿酒酵母蛋白质。酵母 Maf1 是 RNA 聚合酶 III (Pol III) 的负效应子。它响应细胞环境的变化并抑制 pol III 转录。生化研究将起始因子 TFIIIB 确定为 Maf1 依赖性抑制的靶标。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]

MAF1 基因产物(1)

mRNA Protein Name
NM_032272.5 NP_115648.2 repressor of RNA polymerase III transcription MAF1 homolog

MAF1 蛋白结构

Maf1

Maf1: Maf1 regulator (24 - 202)

  • 0
  • 100
  • 200
  • 256 a.a.
蛋白主名 其他名称

repressor of RNA polymerase III transcription MAF1 homolog

MAF1 negative regulator of RNA polymerase III

MAF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAF1 Q9H063 ARMCX3 Homo sapiens Q9UH62
Anti Tag CoIP
33961781
种属内
MAF1 Q9H063 ARMCX3 Homo sapiens Q9UH62
Y2H Array
19060904
种属内
MAF1 Q9H063 ARMCX3 Homo sapiens Q9UH62
Anti Tag CoIP
28514442
种属内
MAF1 Q9H063 ARMCX3 Homo sapiens Q9UH62
Y2H Pooling
19060904
种属内
MAF1 Q9H063 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
MAF1 Q9H063 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
MAF1 Q9H063 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus MAF1 VGNC VGNC:63363
Rattus norvegicus MAF1 RGD RGD:1359315
Bos taurus MAF1 VGNC VGNC:31137
Mus musculus MAF1 MGD MGI:1916127