2. Gene
  3. DDI2 - DNA damage inducible 1 homolog 2 Gene

DDI2 - DNA damage inducible 1 homolog 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DNA 损伤诱导 1 同系物 2

种属: Homo sapiens

基因 ID: 84301 | 基因类型: protein coding

关于 DDI2

This gene has 6 transcripts (splice variants), 164 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues.

功能概要

启用天冬氨酸型内肽酶活性；相同的蛋白质结合活性；和泛素结合活性。参与多个过程，包括细胞对羟基脲的反应；蛋白水解；和 DNA 稳定性的调节。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DDI2 基因产物(1)

mRNA Protein Name
NM_032341.5 NP_115717.3 protein DDI1 homolog 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic-type endopeptidase activity IDA
IDA: 通过直接分析推断
27528193 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
27461074 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27528193 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
27461074 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hydroxyurea IMP
IMP: 通过突变表型推断
29290612 GOA
involved in proteasomal protein catabolic process IMP
IMP: 通过突变表型推断
29290612 GOA
involved in protein processing IDA
IDA: 通过直接分析推断
27528193 GOA
involved in protein processing IMP
IMP: 通过突变表型推断
27676298 GOA
involved in regulation of DNA stability IMP
IMP: 通过突变表型推断
29290612 GOA
involved in regulation of protein stability IMP
IMP: 通过突变表型推断
29290612 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDI2 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (13 - 77)

Asp_protease

Asp_protease: Aspartyl protease (212 - 335)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

protein DDI1 homolog 2

DDI1, DNA-damage inducible 1, homolog 2

关联疾病

疾病名称 别名
Ngly1-Deficiency

Deficiency Of N-Glycanase 1

Ngly1-Cddg

Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome

Ngly1 Deficiency

Congenital Disorder Of Deglycosylation

Congenital Disorder Of Glycosylation Type Iv

Congenital Disorder Of Deglycosylation

Cddg

Congenital Disorder Of Glycosylation Type Iv

Cdg1v
Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS
Combat Disorder

Combat Disorders

Combat Neurosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03612 DDI2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DDI2 MGD MGI:1917244
Rattus norvegicus DDI2 RGD RGD:1311815
Canis familiaris DDI2 VGNC VGNC:52126
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