2. Gene
  3. UTF1 - undifferentiated embryonic cell transcription factor 1 Gene

UTF1 - undifferentiated embryonic cell transcription factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：未分化胚胎细胞转录因子 1

种属: Homo sapiens

基因 ID: 8433 | 基因类型: protein coding

关于 UTF1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,230,217-133,231,558 (from NCBI)

This gene has 1 transcript (splice variant), 48 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是一种含有亮氨酸拉链的转录共激活因子，可将上游激活因子 ATF2 与基础转录复合物连接起来。编码的蛋白质与染色质密切相关，是胚胎癌和胚胎干细胞正常分化所必需的。这种蛋白质几乎完全存在于多能细胞中，也可以用作转录抑制因子。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

UTF1 基因产物(1)

mRNA Protein Name
NM_003577.3 NP_003568.2 undifferentiated embryonic cell transcription factor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9748258 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
9748258 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in male gonad development IEP
IEP: 通过表达模式推断
18281244 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9748258 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18281244 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UTF1 蛋白结构

Myb_DNA-bind_4

Myb_DNA-bind_4: Myb/SANT-like DNA-binding domain (60 - 130)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
蛋白主名 其他名称

undifferentiated embryonic cell transcription factor 1

关联疾病

疾病名称 别名
Spermatocytoma

Spermatocytic Seminoma
Opportunistic Bacterial Infectious Disease
Nocardiosis

Nocardia Infection

Nocardia Infections

Nocardia Infectious Disease

Lung Nocardiosis

Nocardiasis

Nocardiosis Nos
Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm
Germ Cell Cancer

Malignant Germ Cell Tumor

Neoplasms, Germ Cell And Embryonal

Germ Cell Neoplasm

Germ Cell Tumour

Malignant Tumor Of The Germ Cell

Neoplasms Germ Cell

Malignant Germ Cell Neoplasm
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15574 UTF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UTF1 RGD RGD:1589375
Mus musculus UTF1 MGD MGI:1276125
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