2. Gene
  3. BRSK1 - BR serine/threonine kinase 1 Gene

BRSK1 - BR serine/threonine kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BR 丝氨酸/苏氨酸激酶 1

种属: Homo sapiens

同用名: SAD-B; hSAD1

基因 ID: 84446 | 基因类型: protein coding

关于 BRSK1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,283,997-55,312,562 (from NCBI)

This gene has 8 transcripts (splice variants), 131 orthologues and 17 paralogues. Biased expression in brain (RPKM 29.2), adrenal (RPKM 3.5) and 4 other tissues.

功能概要

启用镁离子结合活性；蛋白丝氨酸/苏氨酸激酶活性；和 tau 蛋白激酶活性。参与有丝分裂 G2 DNA 损伤检查点信号和蛋白质磷酸化。作用于有丝分裂细胞周期 G2/M 转换的上游或内部；肽基丝氨酸磷酸化；和对紫外线的反应。位于细胞连接处；细胞质；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables magnesium ion binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in mitotic G2 DNA damage checkpoint signaling and protein phosphorylation. Acts upstream of or within G2/M transition of mitotic cell cycle; peptidyl-serine phosphorylation; and response to UV. Located in cell junction; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BRSK1 基因产物(1)

mRNA Protein Name
NM_032430.2 NP_115806.1 serine/threonine-protein kinase BRSK1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables magnesium ion binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
15150265 GOA
enables tau-protein kinase activity IDA
IDA: 通过直接分析推断
21985311 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
15150265 GOA
acts upstream of or within G2/M transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
15150265 GOA
involved in mitotic G2 DNA damage checkpoint signaling IDA
IDA: 通过直接分析推断
15150265 GOA
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
15150265 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15150265 GOA
acts upstream of or within response to UV IDA
IDA: 通过直接分析推断
15150265 GOA
involved in response to UV IDA
IDA: 通过直接分析推断
15150265 GOA
NOT involved in response to ionizing radiation IDA
IDA: 通过直接分析推断
15150265 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15150265 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15150265 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRSK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (34 - 284)

  • 0
  • 200
  • 400
  • 600
  • 778 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase BRSK1

BR serine/threonine-protein kinase 1

关联疾病

疾病名称 别名
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01637 BRSK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus BRSK1 MGD MGI:2685946
Macaca mulatta BRSK1 VGNC VGNC:70345
Bos taurus BRSK1 VGNC VGNC:50055
Rattus norvegicus BRSK1 RGD RGD:1563268
Felis catus BRSK1 VGNC VGNC:60184
Canis familiaris BRSK1 VGNC VGNC:53668
Others BRSK1 NCBI
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