2. Gene
  3. MEGF11 - multiple EGF like domains 11 Gene

MEGF11 - multiple EGF like domains 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：多个 EGF 样结构域 11

种属: Homo sapiens

基因 ID: 84465 | 基因类型: protein coding

关于 MEGF11

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,895,299-66,253,750 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 198 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues.

功能概要

预计参与同型细胞间粘附和视网膜层形成。预测位于基底外侧质膜。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MEGF11 基因产物(9)

mRNA Protein Name
NM_001385028.1 NP_001371957.1 multiple epidermal growth factor-like domains protein 11 isoform 1 precursor
NM_001385029.1 NP_001371958.1 multiple epidermal growth factor-like domains protein 11 isoform 3 precursor
NM_001385030.1 NP_001371959.1 multiple epidermal growth factor-like domains protein 11 isoform 4
NM_001385031.1 NP_001371960.1 multiple epidermal growth factor-like domains protein 11 isoform 5
NM_001385032.1 NP_001371961.1 multiple epidermal growth factor-like domains protein 11 isoform 6
NM_001385033.1 NP_001371962.1 multiple epidermal growth factor-like domains protein 11 isoform 7 precursor
NM_001387150.1 NP_001374079.1 multiple epidermal growth factor-like domains protein 11 isoform 2 precursor
NM_001387151.1 NP_001374080.1 multiple epidermal growth factor-like domains protein 11 isoform 8 precursor
NM_032445.3 NP_115821.2 multiple epidermal growth factor-like domains protein 11 isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MEGF11 蛋白结构

hEGF

hEGF: Human growth factor-like EGF (203 - 215)

hEGF

hEGF: Human growth factor-like EGF (247 - 258)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (275 - 320)

hEGF

hEGF: Human growth factor-like EGF (333 - 344)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (362 - 407)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (450 - 493)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (579 - 619)

hEGF

hEGF: Human growth factor-like EGF (639 - 650)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (667 - 703)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (753 - 790)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (796 - 824)

  • 0
  • 200
  • 400
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  • 1044 a.a.
蛋白主名 其他名称

multiple epidermal growth factor-like domains protein 11

multiple EGF-like domains protein 11

MEGF11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MEGF11 A6BM72 NUFIP2 Homo sapiens Q7Z417
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

EMARDD

Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant

Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome

Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia

Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Folic Acid Deficiency Anemia

Folate Deficiency Anaemia

Folic Acid Deficiency Anaemia

Folate Deficiency Anemia

Folate-Deficiency Anaemia

Folate-Deficiency Anemia

Folate-Deficient Megaloblastic Anaemia

Megaloblastic Anemia Due To Folate Deficiency

Anaemia Of Folate Deficiency

Folate Or Folic Acid Deficiency Anaemia Nos

Folic Acid Deficiency Anaemia Nos

Acquired Megaloblastic Anaemia Due To Nutritional Folate Deficiency

Dietary Folic Acid Deficiency Anaemia

Dietary Folate Deficiency Anaemia

Folate Deficiency Anaemia Due To Dietary Causes

Goat'S Milk Anaemia

Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Increased Requirement

Megaloblastic Anaemia Due To Increased Requirements Of Folate

Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Intestinal Disorders

Acquired Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate

Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate
Carpenter Syndrome 1

Carpenter Syndrome

Acrocephalopolysyndactyly Type Ii

Acps Ii

CRPT1

Acrocephalopolysyndactyly Type 2

Acrocephalosyndactyly, Type Ii

Acrocephalopolysyndactyly 2

Acps2

Acps 2

Type Ii Acrocephalosyndactyly

Carpenter Syndrome, Type 1

Apert-Crouzon Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08315 MEGF11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MEGF11 MGD MGI:1920951
Felis catus MEGF11 VGNC VGNC:80915
Macaca mulatta MEGF11 VGNC VGNC:84376
Bos taurus MEGF11 VGNC VGNC:55123
Rattus norvegicus MEGF11 RGD RGD:1582797
Canis familiaris MEGF11 VGNC VGNC:59120
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