2. Gene
  3. SPIRE2 - spire type actin nucleation factor 2 Gene

SPIRE2 - spire type actin nucleation factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：螺旋型肌动蛋白成核因子 2

种属: Homo sapiens

同用名: Spir-2

基因 ID: 84501 | 基因类型: protein coding

关于 SPIRE2

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,828,475-89,871,319 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 1 paralogue. Broad expression in stomach (RPKM 4.5), colon (RPKM 4.1) and 20 other tissues.

功能概要

预测启用肌动蛋白结合活性。参与建立减数分裂纺锤体定位；形成核肌动蛋白电缆组件；和双链断裂修复的正调控。预测位于细胞骨架中；胞质溶胶；和质膜。预测在细胞皮层和细胞质囊泡膜中有活性。预测与卵裂沟共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable actin binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Predicted to colocalize with cleavage furrow. [provided by Alliance of Genome Resources, Apr 2022]

SPIRE2 基因产物(1)

mRNA Protein Name
NM_032451.2 NP_115827.1 protein spire homolog 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
21620703 GOA
involved in establishment of meiotic spindle localization IMP
IMP: 通过突变表型推断
21620703 GOA
involved in formin-nucleated actin cable assembly IMP
IMP: 通过突变表型推断
26287480 GOA
involved in positive regulation of double-strand break repair IMP
IMP: 通过突变表型推断
26287480 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein spire homolog 2

spire actin nucleation factor 2

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia

Familial Hyperbetalipoproteinaemia

Familial Hypercholesteremia

Fredrickson Type Iia Hyperlipoproteinemia

Fredrickson Type Iia Lipidaemia

Hyperbetalipoproteinemia

Type Ii Hyperlipidemia

Familial Hypercholesterolæmia

Familial Hypercholesterolaemia

Fh

Hypercholesterolemia Familial

Hyperlipoproteinemia Type Ii

Hypercholesterolemia, Familial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13688 SPIRE2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-161011 Spire2-FMN2 interaction-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SPIRE2 MGD MGI:2446256
Felis catus SPIRE2 VGNC VGNC:65641
Macaca mulatta SPIRE2 VGNC VGNC:78023
Canis familiaris SPIRE2 VGNC VGNC:46749
Bos taurus SPIRE2 VGNC VGNC:35223
Rattus norvegicus SPIRE2 RGD RGD:1305837
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