1. Gene
  2. DCTN5 - dynactin subunit 5 Gene

DCTN5 - dynactin subunit 5 Gene

中文名称:动力蛋白亚基 5

种属: Homo sapiens

基因 ID: 84516 | 基因类型: protein coding

关于 DCTN5

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,641,466-23,677,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in brain (RPKM 13.0), testis (RPKM 7.5) and 25 other tissues.

功能概要

该基因编码动力蛋白的一个亚基,动力蛋白是参与负端定向运输的细胞质动力蛋白运动机械的一个组成部分。编码的蛋白质是尖端子复合体的一个组成部分,被认为可以结合膜状货物。该基因的假基因位于 1 号染色体的长臂上。已观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 1 月]

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

DCTN5 基因产物(3)

mRNA Protein Name
NM_001199011.2 NP_001185940.1 dynactin subunit 5 isoform 2
NM_001199743.2 NP_001186672.1 dynactin subunit 5 isoform 3
NM_032486.4 NP_115875.1 dynactin subunit 5 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DCTN5 蛋白结构

Hexapep

Hexapep: Bacterial transferase hexapeptide (six repeats) (101 - 128)

  • 0
  • 100
  • 182 a.a.
蛋白主名 其他名称

dynactin subunit 5

dynactin 4

DCTN5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCTN5 Q9BTE1 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra DCTN5 Q9BTE1 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra DCTN5 Q9BTE1 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra DCTN5 Q9BTE1 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Dominant Nonsyndromic Deafness 77

Dfna77

Charcot-Marie-Tooth Disease, Axonal, Type 2o

Charcot-Marie-Tooth Disease Axonal Type 2o

CMT2O

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2o

Charcot-Marie-Tooth Neuropathy Axonal Type 2o

Charcot-Marie-Tooth Neuropathy, Axonal, Type 2o

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2o

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2o

Charcot-Marie-Tooth Disease 2o

Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2o

Joubert Syndrome 17

JBTS17

Joubert Syndrome, Type 17

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DCTN5 VGNC VGNC:61381
Macaca mulatta DCTN5 VGNC VGNC:71703
Bos taurus DCTN5 VGNC VGNC:27932
Canis familiaris DCTN5 VGNC VGNC:39820
Rattus norvegicus DCTN5 RGD RGD:1305654
Mus musculus DCTN5 MGD MGI:1891689
Others DCTN5 NCBI