2. Gene
  3. Hdac5 - histone deacetylase 5 Gene

Hdac5 - histone deacetylase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 5

种属: Rattus norvegicus

基因 ID: 84580 | 基因类型: protein coding

关于 Hdac5

Primary_assembly 10: 87,152,978-87,188,235 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 194 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 189.9), Brain (RPKM 149.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性。参与多个过程，包括细胞对脂多糖的反应；对活动的反应；和对可卡因的反应。位于细胞质和细胞核中。部分含蛋白质复合物。急性肾功能衰竭的生物标志物；精神抑郁症；大脑中动脉梗塞;和肺动脉高压。与人类 HDAC5（组蛋白脱乙酰酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to activity; and response to cocaine. Located in cytoplasm and nucleus. Part of protein-containing complex. Biomarker of acute kidney failure; mental depression; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 基因产物(1)

mRNA Protein Name
NM_053450.1 NP_445902.1 histone deacetylase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
19638401 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
22933299 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
12850547 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
21198979 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
21954104 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16767219 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12896970 RGD
located in nucleus IDA
IDA: 通过直接分析推断
12896970 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
22360269 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hdac5 蛋白结构

ClassIIa_HDAC_Gln-rich-N

ClassIIa_HDAC_Gln-rich-N: cl25407 (86 - 173)

Arginase_HDAC

Arginase_HDAC: cl17011 (688 - 1104)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1120 a.a.
蛋白主名 其他名称

histone deacetylase 5

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13322 Pracinostat Inhibitor 99.82% 是
Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
Pre-clinical Phase
生物活性分子 (28)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18361 TMP195 Inhibitor 99.57% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-112719 BRD 4354 Inhibitor 99.66% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-143248 KR-39038 Inhibitor 99.48% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-149285 NT160 Inhibitor 99.58% 否
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac5 NCBI NCBI:10014
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