2. Gene
  3. ST6GAL2 - ST6 beta-galactoside alpha-2,6-sialyltransferase 2 Gene

ST6GAL2 - ST6 beta-galactoside alpha-2,6-sialyltransferase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ST6 β-半乳糖苷 α-2,6-唾液酸转移酶 2

种属: Homo sapiens

同用名: SIAT2; ST6GalII

基因 ID: 84620 | 基因类型: protein coding

关于 ST6GAL2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:106,801,600-106,887,277 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 14 paralogues. Biased expression in thyroid (RPKM 11.0), brain (RPKM 3.9) and 3 other tissues.

功能概要

该基因座编码唾液酸转移酶。编码的 II 型跨膜蛋白催化唾液酸从 CMP 转移到寡糖底物。该基因座的多态性可能与精神分裂症患者利培酮反应的变化有关。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2012 年 1 月]

This locus encodes a Sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

ST6GAL2 基因产物(4)

mRNA Protein Name
NM_001142351.2 NP_001135823.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
NM_001142352.2 NP_001135824.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform b
NM_001322362.2 NP_001309291.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
NM_032528.3 NP_115917.1 beta-galactoside alpha-2,6-sialyltransferase 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-galactoside alpha-2,6-sialyltransferase activity IDA
IDA: 通过直接分析推断
12235148 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in oligosaccharide metabolic process IDA
IDA: 通过直接分析推断
12235148 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ST6GAL2 蛋白结构

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (265 - 503)

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  • 529 a.a.
蛋白主名 其他名称

beta-galactoside alpha-2,6-sialyltransferase 2

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2

关联疾病

疾病名称 别名
Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13853 ST6GAL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ST6GAL2 VGNC VGNC:77824
Canis familiaris ST6GAL2 VGNC VGNC:46857
Rattus norvegicus ST6GAL2 RGD RGD:1559663
Felis catus ST6GAL2 VGNC VGNC:65727
Bos taurus ST6GAL2 VGNC VGNC:35338
Mus musculus ST6GAL2 MGD MGI:2445190
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