2. Gene
  3. PSRC1 - proline and serine rich coiled-coil 1 Gene

PSRC1 - proline and serine rich coiled-coil 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富脯氨酸和丝氨酸的卷曲螺旋 1

种属: Homo sapiens

同用名: DDA3; FP3214

基因 ID: 84722 | 基因类型: protein coding

关于 PSRC1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,279,556-109,283,145 (from NCBI)

This gene has 12 transcripts (splice variants), 106 orthologues and 1 paralogue. Broad expression in brain (RPKM 9.0), testis (RPKM 4.6) and 23 other tissues.

功能概要

该基因编码一种富含脯氨酸的蛋白质，该蛋白质是肿瘤抑制蛋白 p53 调节的靶标。编码的蛋白质通过募集和调节使微管不稳定的微管解聚酶在有丝分裂中发挥重要作用。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

PSRC1 基因产物(14)

mRNA Protein Name
NM_001005290.4 NP_001005290.1 proline/serine-rich coiled-coil protein 1 isoform b
NM_001032291.3 NP_001027462.1 proline/serine-rich coiled-coil protein 1 isoform a
NM_001350237.2 NP_001337166.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350238.2 NP_001337167.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350239.2 NP_001337168.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350240.2 NP_001337169.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350241.2 NP_001337170.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350242.2 NP_001337171.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001363309.2 NP_001350238.1 proline/serine-rich coiled-coil protein 1 isoform c
NM_001394002.1 NP_001380931.1 proline/serine-rich coiled-coil protein 1 isoform a
NM_001394003.1 NP_001380932.1 proline/serine-rich coiled-coil protein 1 isoform b
NM_001394004.1 NP_001380933.1 proline/serine-rich coiled-coil protein 1 isoform b
NM_001394005.1 NP_001380934.1 proline/serine-rich coiled-coil protein 1 isoform c
NM_032636.8 NP_116025.1 proline/serine-rich coiled-coil protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18411309 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic metaphase chromosome alignment IDA
IDA: 通过直接分析推断
18411309 GOA
involved in regulation of mitotic spindle organization IDA
IDA: 通过直接分析推断
18411309 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
18411309 GOA
colocalizes with spindle microtubule IDA
IDA: 通过直接分析推断
18411309 GOA
colocalizes with spindle pole IDA
IDA: 通过直接分析推断
18411309 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSRC1 蛋白结构

GTSE1_N

GTSE1_N: G-2 and S-phase expressed 1 (7 - 104)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
蛋白主名 其他名称

proline/serine-rich coiled-coil protein 1

differential display and activated by p53

PSRC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PSRC1 Q6PGN9 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pulmonary Embolism And Infarction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11343 PSRC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PSRC1 VGNC VGNC:33484
Felis catus PSRC1 VGNC VGNC:64418
Canis familiaris PSRC1 VGNC VGNC:45125
Rattus norvegicus PSRC1 RGD RGD:1585037
Macaca mulatta PSRC1 VGNC VGNC:76307
Mus musculus PSRC1 MGD MGI:1913099
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