UNC119B - unc-119 lipid binding chaperone B Gene

中文名称：unc-119 脂质结合伴侣 B

种属: Homo sapiens

同用名: POC7B

基因 ID: 84747 | 基因类型: protein coding

关于 UNC119B

This gene has 3 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 22.0), ovary (RPKM 19.5) and 24 other tissues.

功能概要

启用脂质结合活性。参与纤毛组装和脂蛋白转运。位于睫状移行区。 [由基因组资源联盟提供，2022 年 4 月]

Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2022]

UNC119B 基因产物(1)

mRNA	Protein	Name
NM_001080533.3	NP_001074002.1	protein unc-119 homolog B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables lipid binding	IDA IDA: 通过直接分析推断	22085962	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22085962	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cilium assembly	IMP IMP: 通过突变表型推断	22085962	GOA
involved in lipoprotein transport	IDA IDA: 通过直接分析推断	22085962	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in ciliary transition zone	IDA IDA: 通过直接分析推断	22085962	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UNC119B 蛋白结构

GMP_PDE_delta

0
100
200
251 a.a.

蛋白主名

其他名称

protein unc-119 homolog B

POC7 centriolar protein homolog B

UNC119B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UNC119B	A6NIH7	NPHP3	Homo sapiens	Q7Z494	FPS	22960633

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Macular Degeneration, X-Linked Atrophic

X-Linked Atrophic Macular Degeneration	Macular Degeneration, X-Linked, Atrophic
MDXLA	Degeneration, Macular, X-Linked Atrophic

Joubert Syndrome 22

JBTS22

Joubert Syndrome, Type 22

Retinitis Pigmentosa 2

RP2	X-Linked Retinitis Pigmentosa 2
Xlrp2	Xlrp-2
Retinitis Pigmentosa-2	Retinitis Pigmentosa, Type 2

Nephronophthisis 2

NPHP2	Nph2
Nephronophthisis 2, Infantile	Infantile Nephronophthisis 2
Infantile Nephronophthisis	Nephronophthisis, Type 2

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-164368	GLUT4 activator 2	Activator	/	否
HY-RS15463	UNC119B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	UNC119B	VGNC	VGNC:66821
Rattus norvegicus	UNC119B	RGD	RGD:1309359
Mus musculus	UNC119B	MGD	MGI:2147162
Bos taurus	UNC119B	VGNC	VGNC:36663
Canis familiaris	UNC119B	VGNC	VGNC:48134

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